Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Garza Cervantes, Javier A. y Chávez Reyes, Arturo y Castillo, Elena C. y García Rivas, Gerardo y Antonio Ortega Rivera, Oscar y Salinas, Eva y Ortiz-Martínez, Margarita y Gómez Flores, Sara Leticia y Peña Martínez, Jorge A. y Pepi Molina, Alan y Treviño González, Mario T. y Zarate, Xristo y Elena Cantú Cárdenas, María y Enrique Escarcega Gonzalez, Carlos y Morones Ramírez, J. Rubén (2017) Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments. Scientific reports, 7 (1). pp. 1-16. ISSN 2045-2322

[img]
Vista previa
Texto
10.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (3MB) | Vista previa

Resumen

Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E. coli and B. subtilis. We find that most combinatorial treatments exhibit synergistic antimicrobial effects at low/ non-toxic concentrations to human keratinocyte cells, blast and melanoma rat cell lines. Moreover, we show that silver/(Cu, Ni, and Zn) increase prokaryotic cell permeability at sub-inhibitory concentrations, demonstrating this to be a possible mechanism of the synergistic behavior. Together, these results suggest that these combinatorial treatments will play an important role in the future development of antimicrobial agents and treatments against infections. In specific, the cytotoxicity experiments show that the combinations have great potential in the treatment of topical infections.

Tipo de elemento: Article
Divisiones: Ciencias Químicas
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Garza Cervantes, Javier A.NO ESPECIFICADONO ESPECIFICADO
Chávez Reyes, ArturoNO ESPECIFICADONO ESPECIFICADO
Castillo, Elena C.NO ESPECIFICADONO ESPECIFICADO
García Rivas, GerardoNO ESPECIFICADONO ESPECIFICADO
Antonio Ortega Rivera, OscarNO ESPECIFICADONO ESPECIFICADO
Salinas, EvaNO ESPECIFICADONO ESPECIFICADO
Ortiz-Martínez, MargaritaNO ESPECIFICADONO ESPECIFICADO
Gómez Flores, Sara LeticiaNO ESPECIFICADONO ESPECIFICADO
Peña Martínez, Jorge A.NO ESPECIFICADONO ESPECIFICADO
Pepi Molina, AlanNO ESPECIFICADONO ESPECIFICADO
Treviño González, Mario T.NO ESPECIFICADONO ESPECIFICADO
Zarate, XristoNO ESPECIFICADONO ESPECIFICADO
Elena Cantú Cárdenas, MaríaNO ESPECIFICADONO ESPECIFICADO
Enrique Escarcega Gonzalez, CarlosNO ESPECIFICADONO ESPECIFICADO
Morones Ramírez, J. RubénNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 17 Jul 2018 18:33
Última modificación: 17 Jul 2018 18:33
URI: http://eprints.uanl.mx/id/eprint/14487

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year