Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Garza Cervantes, Javier Alberto y Chávez Reyes, Arturo y Castillo, Elena C. y García Rivas, Gerardo y Ortega Rivera, Oscar Antonio y Salinas, Eva y Ortiz Martínez, Margarita y Gómez Flores, Sara Leticia y Peña Martínez, Jorge Arturo y Pepi Molina, Alan y Treviño Gonzalez, Mario Tadeo y Zárate Kalfópulos, Xristo y Cantú Cárdenas, María Elena y Escárcega González, Carlos Enrique y Morones Ramírez, José Rubén (2017) Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments. Scientific reports, 7 (1). pp. 1-16. ISSN 2045-2322

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Resumen

Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E. coli and B. subtilis. We find that most combinatorial treatments exhibit synergistic antimicrobial effects at low/ non-toxic concentrations to human keratinocyte cells, blast and melanoma rat cell lines. Moreover, we show that silver/(Cu, Ni, and Zn) increase prokaryotic cell permeability at sub-inhibitory concentrations, demonstrating this to be a possible mechanism of the synergistic behavior. Together, these results suggest that these combinatorial treatments will play an important role in the future development of antimicrobial agents and treatments against infections. In specific, the cytotoxicity experiments show that the combinations have great potential in the treatment of topical infections.

Tipo de elemento: Article
Divisiones: Ciencias Químicas
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Garza Cervantes, Javier AlbertoNO ESPECIFICADONO ESPECIFICADO
Chávez Reyes, ArturoNO ESPECIFICADONO ESPECIFICADO
Castillo, Elena C.NO ESPECIFICADONO ESPECIFICADO
García Rivas, GerardoNO ESPECIFICADONO ESPECIFICADO
Ortega Rivera, Oscar AntonioNO ESPECIFICADONO ESPECIFICADO
Salinas, EvaNO ESPECIFICADONO ESPECIFICADO
Ortiz Martínez, MargaritaNO ESPECIFICADONO ESPECIFICADO
Gómez Flores, Sara LeticiaNO ESPECIFICADONO ESPECIFICADO
Peña Martínez, Jorge Arturojorge.penamrtz@uanl.edu.mxNO ESPECIFICADO
Pepi Molina, AlanNO ESPECIFICADONO ESPECIFICADO
Treviño Gonzalez, Mario TadeoNO ESPECIFICADONO ESPECIFICADO
Zárate Kalfópulos, XristoNO ESPECIFICADONO ESPECIFICADO
Cantú Cárdenas, María ElenaNO ESPECIFICADONO ESPECIFICADO
Escárcega González, Carlos EnriqueNO ESPECIFICADONO ESPECIFICADO
Morones Ramírez, José RubénNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 17 Jul 2018 18:33
Última modificación: 06 Mar 2024 18:46
URI: http://eprints.uanl.mx/id/eprint/14487

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