Do immunoglobulin G and immunoglobulin E anti- l -asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study

Galindo Rodríguez, Gabriela y Jaime Pérez, José Carlos y Salinas Carmona, Mario César y González Díaz, Sandra N. y Castro Corona, Ángeles y Cavazos González, Raúl y Treviño Villarreal, Humberto y Heredia Salazar, Alberto Carlos y Gómez Almaguer, David (2017) Do immunoglobulin G and immunoglobulin E anti- l -asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study. Revista Brasileira de Hematologia e Hemoterapia, 39 (3). pp. 202-209. ISSN 15168484

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Background: l-Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti-l-asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity reactions, in which immunoglobulin E can also participate. This study investigated the presence of immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies and their clinical associations. Methods: Under 16-year-old patients at diagnosis of B-cell acute lymphoblastic leukemia confirmed by flow cytometry and treated with a uniform l-asparaginase and chemotherapy protocol were studied. Immunoglobulin G anti-l-asparaginase antibodies were measured using an enzyme-linked immunosorbent assay. Intradermal and prick skin testing was performed to establish the presence of specific immunoglobulin E anti-l-asparaginase antibodies in vivo. Statistical analysis was used to investigate associations of these antibodies with relevant clinical events and outcomes. Results: Fifty-one children were studied with 42 (82.35%) having anti-l-asparaginase antibodies. In this group immunoglobulin G antibodies alone were documented in 10 (23.8%) compared to immunoglobulin E alone in 18 (42.8%) patients. Immunoglobulin G together with immunoglobulin E were simultaneously present in 14 patients. Children who produced exclusively immunoglobulin G or no antibodies had a lower event-free survival (p-value = 0.024). Eighteen children (35.3%) relapsed with five of nine of this group who had negative skin tests suffering additional relapses (range: 2–4), compared to none of the nine children who relapsed who had positive skin tests (p-value < 0.001). Conclusion: Children with acute lymphoblastic leukemia and isolated immunoglobulin G anti-l-asparaginase antibodies had a higher relapse rate, whereas no additional relapses developed in children with immunoglobulin E anti-l-asparaginase antibodies after the first relapse.

Tipo de elemento: Article
Palabras claves no controlados: Acute Lymphoblastic leukemia, Allergy, hypersensitivity, L-Asparaginase, Neutralizing antibodies, Silent antibodies
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Galindo Rodríguez, GabrielaNO ESPECIFICADONO ESPECIFICADO
Jaime Pérez, José CarlosNO ESPECIFICADONO ESPECIFICADO
Salinas Carmona, Mario CésarNO ESPECIFICADONO ESPECIFICADO
González Díaz, Sandra N.NO ESPECIFICADONO ESPECIFICADO
Castro Corona, ÁngelesNO ESPECIFICADONO ESPECIFICADO
Cavazos González, RaúlNO ESPECIFICADONO ESPECIFICADO
Treviño Villarreal, HumbertoNO ESPECIFICADONO ESPECIFICADO
Heredia Salazar, Alberto CarlosNO ESPECIFICADONO ESPECIFICADO
Gómez Almaguer, DavidNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 19 Mayo 2020 17:20
Última modificación: 09 Jun 2020 20:15
URI: http://eprints.uanl.mx/id/eprint/14577

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