Salivary ammonia levels and Tannerella forsythia are associated with rheumatoid arthritis: A cross sectional study

Martínez Rivera, José-Iván y Xibillé Friedmann, Daniel X. y González Christen, Judith y de la Garza Ramos, Myriam A. y Carrillo Vázquez, Sandra M. y Montiel Hernández, José-Luis (2017) Salivary ammonia levels and Tannerella forsythia are associated with rheumatoid arthritis: A cross sectional study. Clinical and Experimental Dental Research, 3 (3). pp. 107-114. ISSN 20574347

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URL o página oficial: http://doi.org/10.1002/cre2.68

Resumen

The aim of this paper is to evaluate the relationship of salivary ammonium levels and the presence of bacteria with rheumatoid arthritis (RA) clinical disease activity in a cross‐sectional study of Mexican patients. From a periodontal and disease activity standpoint, 132 consecutive RA patients fulfilling clinical criteria were evaluated. Ammonia levels (including peptidyl arginine deiminase activity) were evaluated by colorimetric assay and the presence of Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia was evaluated by polymerase chain reaction (PCR) technique. After a multivariate analysis, adjusting for clinical and serological parameters, a significant association was only observed between severe periodontitis and probing depth with high RA disease activity. Additionally, in contrast to P. gingivalis, the presence of T. forsythia was significantly associated with high disease RA activity even after multivariable adjustment analysis. There was also a significant increase in ammonium levels in the high RA activity group and a significant correlation between salivary ammonia and RA disease activity but not with autoantibody titers. Similarly, we observed a significant increase in the ammonium levels derived from the cultures of P. gingivalis and T. forsythia, with respect to P. intermedia and S. gordonii cultures, or even healthy donors. These results suggest that RA activity is associated with severe periodontitis, high salivary ammonium levels and the presence of T. forsythia.

Tipo de elemento: Article
Palabras claves no controlados: Periodontitis, Rheumatoid arthritis, T. forsythia, Salivary ammonia levels
Materias: R Medicina > RK Odontología
Divisiones: Odontología
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Martínez Rivera, José-IvánNO ESPECIFICADONO ESPECIFICADO
Xibillé Friedmann, Daniel X.NO ESPECIFICADONO ESPECIFICADO
González Christen, JudithNO ESPECIFICADONO ESPECIFICADO
de la Garza Ramos, Myriam A.NO ESPECIFICADONO ESPECIFICADO
Carrillo Vázquez, Sandra M.NO ESPECIFICADONO ESPECIFICADO
Montiel Hernández, José-LuisNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 26 Mayo 2020 16:27
Última modificación: 26 Mayo 2020 16:27
URI: http://eprints.uanl.mx/id/eprint/14593

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