Hyperpigmentation following Treatment of Frontal Fibrosing Alopecia

Pérez Rodríguez, Irma Margarita y García Melendez, Martha Elena y Eichelmann, Kristian y Vázquez Martínez, Osvaldo y Ocampo Candiani, Jorge (2013) Hyperpigmentation following Treatment of Frontal Fibrosing Alopecia. Case Reports in Dermatology, 5 (3). pp. 357-362. ISSN 1662-6567

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URL o página oficial: http://doi.org/10.1159/000357022

Resumen

Introduction: Frontal fibrosing alopecia (FFA) is a scarring alopecia characterized by progressive recession of the frontotemporal hairline. Current treatment is aimed at stopping progression, and the combination of dutasteride and pimecrolimus is the most effective therapy. Side effects associated with dutasteride are erectile dysfunction as well as breast tenderness and enlargement, while pimecrolimus produces a burning sensation. Case Report: We present a 57-year-old postmenopausal female with a 3-year history of a scarring alopecic plaque in her frontotemporal region. Biopsy confirmed the diagnosis of FFA, and she was started on dutasteride 0.5 mg p.o. q.d., and later, topical pimecrolimus 1% b.i.d. was added. Eight months after initiating treatment, she showed hyperpigmentation on her metacarpophalangeal and interphalangeal joints, as well as on the cheeks and on the chin; dutasteride and pimecrolimus were discontinued. After 5 months of follow-up, her hyperpigmentation improved by 80% only by using photoprotection. Conclusion: Because of the variable clinical course of FFA, treatment is focused on halting its progression. Several therapeutic agents have been evaluated and the combination of dutasteride and pimecrolimus has shown a high response rate. There is no reported evidence of hyperpigmentation associated with this combination.

Tipo de elemento: Article
Palabras claves no controlados: Hyperpigmentation · Frontal fibrosing alopecia · Scarring alopecia
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Pérez Rodríguez, Irma MargaritaNO ESPECIFICADONO ESPECIFICADO
García Melendez, Martha ElenaNO ESPECIFICADONO ESPECIFICADO
Eichelmann, KristianNO ESPECIFICADONO ESPECIFICADO
Vázquez Martínez, OsvaldoNO ESPECIFICADONO ESPECIFICADO
Ocampo Candiani, JorgeNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 26 Ago 2020 02:43
Última modificación: 26 Ago 2020 02:43
URI: http://eprints.uanl.mx/id/eprint/14668

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