Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats

Cordero Pérez, Paula y Aguirre Garza, Marcelino y Camara Lemarroy, Carlos y Alarcón Galván, Gabriela y Cantú Sepúlveda, Daniel y Bernal Ramirez, Judith y Torres González, Liliana y Guzmán de la Garza, Francisco y Zapata Chavira, Homero y Sotelo Gallegos, Made Jesús y Torres Esquivel, CipactliNadjedja y Sánchez Fresno, Ethel y González Saldivar, Gerardo y Muñoz Espinosa, LindaE (2013) Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats. Pharmacognosy Research, 5 (3). p. 150. ISSN 0974-8490

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Resumen

Background: The antioxidant and anti-inflammatory effects of arbutin protect against a number of diseases. Objectives: The present study evaluated the protective effect of arbutin against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Sixty-three Wistar rats were divided into nine groups. Groups I and II were the normal control groups. Group III, the hepatotoxic group, was given CCl4. Groups IV, VI, and VIII received different dosages of arbutin along with CCl4. Groups V, VII, and IX were administered different dosages of arbutin. The albumin content, total protein, and bilirubin were assayed to determine their serum and antioxidant levels; lipid peroxidation was assessed in the serum and liver tissue. Histological studies were carried out to confirm the biochemical results. Results: Treatment with CCl4 for 28 d decreased the levels of total protein and albumin and increased the level of bilirubin and lipid peroxidation. Arbutin treatment raised the level of albumin and lowered the lipid peroxidation to normal levels. Necrosis and fibrosis were observed in the liver tissue of CCl4-injected rats, and the administration of arbutin had a protective effect on the liver tissue. Conclusions: The results of this study showed that arbutin may protect the liver against CCl4-induced oxidative damage in rats. This hepatoprotective effect might be correlated with the antioxidant and free radical scavenger effects of arbutin.

Tipo de elemento: Article
Palabras claves no controlados: Antioxidants, Arbutin, Carbon Tetrachloride Poisoning, Hepatoprotective
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Cordero Pérez, PaulaNO ESPECIFICADONO ESPECIFICADO
Aguirre Garza, MarcelinoNO ESPECIFICADONO ESPECIFICADO
Camara Lemarroy, CarlosNO ESPECIFICADONO ESPECIFICADO
Alarcón Galván, GabrielaNO ESPECIFICADONO ESPECIFICADO
Cantú Sepúlveda, DanielNO ESPECIFICADONO ESPECIFICADO
Bernal Ramirez, JudithNO ESPECIFICADONO ESPECIFICADO
Torres González, LilianaNO ESPECIFICADONO ESPECIFICADO
Guzmán de la Garza, FranciscoNO ESPECIFICADONO ESPECIFICADO
Zapata Chavira, HomeroNO ESPECIFICADONO ESPECIFICADO
Sotelo Gallegos, Made JesúsNO ESPECIFICADONO ESPECIFICADO
Torres Esquivel, CipactliNadjedjaNO ESPECIFICADONO ESPECIFICADO
Sánchez Fresno, EthelNO ESPECIFICADONO ESPECIFICADO
González Saldivar, GerardoNO ESPECIFICADONO ESPECIFICADO
Muñoz Espinosa, LindaENO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 26 Ago 2020 02:48
Última modificación: 26 Ago 2020 02:48
URI: http://eprints.uanl.mx/id/eprint/14687

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