Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?

García Compeán, Diego y González González, José Alberto y Lavalle González, Fernando Javier y González Moreno, Emmanuel Irineo y Villarreal Pérez, Jesús Zacarías y Maldonado Garza, Héctor Jesús (2016) Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? World Journal of Gastroenterology, 22 (10). p. 2869. ISSN 1007-9327

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Resumen

Diabetes mellitus (DM) that occurs because of chronic liver disease (CLD) is known as hepatogenous diabetes (HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus (HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease.

Tipo de elemento: Article
Palabras claves no controlados: Hepatogenous diabetes, Diabetes mellitus, Outcomes, Therapy, Hepatitis C virus, Chronic liver disease
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
García Compeán, DiegoNO ESPECIFICADONO ESPECIFICADO
González González, José AlbertoNO ESPECIFICADONO ESPECIFICADO
Lavalle González, Fernando JavierNO ESPECIFICADONO ESPECIFICADO
González Moreno, Emmanuel IrineoNO ESPECIFICADONO ESPECIFICADO
Villarreal Pérez, Jesús ZacaríasNO ESPECIFICADONO ESPECIFICADO
Maldonado Garza, Héctor JesúsNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 29 Mayo 2019 14:15
Última modificación: 13 Ago 2019 18:21
URI: http://eprints.uanl.mx/id/eprint/14830

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