Flourensia cernua: Hexane Extracts a Very Active Mycobactericidal Fraction from an Inactive Leaf Decoction against Pansensitive and PanresistantMycobacterium tuberculosis

Molina Salinas, Gloria María y Peña Rodríguez, Luis Manuel y Mata Cárdenas, Benito David y Escalante Erosa, Fabiola y González Hernández, Silvia y Torres de la Cruz, Víctor Manuel y Martínez Rodríguez, Herminia Guadalupe y Said Fernández, Salvador (2011) Flourensia cernua: Hexane Extracts a Very Active Mycobactericidal Fraction from an Inactive Leaf Decoction against Pansensitive and PanresistantMycobacterium tuberculosis. Evidence-Based Complementary and Alternative Medicine, 2011. pp. 1-9. ISSN 1741-427X

[img]
Vista previa
Texto
690.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (559kB) | Vista previa
URL o página oficial: http://doi.org/10.1155/2011/782503

Resumen

The efficacy of decoction in extracting mycobactericidal compounds from Flourensia cernua (Hojas´e) leaves and fractionation with solvents having ascending polarity was compared with that of (i) ethanol extraction by still maceration, extraction with a Soxhlet device, shake-assisted maceration, or ultrasound-assisted maceration, followed by fractionation with n-hexane, ethyl acetate, and n-butanol; (ii) sequential extraction with n-hexane, ethyl acetate, and n-butanol, by still maceration, using a Soxhlet device, shake-assisted maceration, or ultrasound-assisted maceration. The in vitro mycobactericidal activity of each preparation was measured against drug-sensitive (SMtb) and drug-resistant (RMtb) Mycobacterium tuberculosis strains. The results of which were expressed as absolute mycobactericidal activity (AMA). These data were normalized to the ΣAMA of the decoction fraction set. Although decoction was inactive, the anti-RMtb normalized ΣAMA (NAMA) of its fractions was comparable with the anti-RMtb NAMA of the still maceration extracts and significantly higher than the anti-SMtb and anti-RMtb NAMAs of every other ethanol extract and serial extract and fraction. Hexane extracted, from decoction, material having 55.17% and 92.62% of antituberculosis activity against SMtb and RMtb, respectively. Although the mycobactericidal activity of decoction is undetectable; its efficacy in extracting F. cernua active metabolites against M. tuberculosis is substantially greater than almost all pharmacognostic methods.

Tipo de elemento: Article
Materias: Q Ciencia > QR Microbiología
Divisiones: Ciencias Químicas
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Molina Salinas, Gloria MaríaNO ESPECIFICADONO ESPECIFICADO
Peña Rodríguez, Luis ManuelNO ESPECIFICADONO ESPECIFICADO
Mata Cárdenas, Benito DavidNO ESPECIFICADONO ESPECIFICADO
Escalante Erosa, FabiolaNO ESPECIFICADONO ESPECIFICADO
González Hernández, SilviaNO ESPECIFICADONO ESPECIFICADO
Torres de la Cruz, Víctor ManuelNO ESPECIFICADONO ESPECIFICADO
Martínez Rodríguez, Herminia GuadalupeNO ESPECIFICADONO ESPECIFICADO
Said Fernández, SalvadorNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 06 Mayo 2019 21:16
Última modificación: 06 Mayo 2019 21:16
URI: http://eprints.uanl.mx/id/eprint/15063

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year