Identification of viral infections in the prostate and evaluation of their association with cancer

Martinez Fierro, Margarita L y Leach, Robin J y Gomez Guerra, Lauro S y Garza Guajardo, Raquel y Johnson Pais, Teresa y Beuten, Joke y Morales Rodríguez, Idelma Berenise y Hernandez Ordoñez, Mario A y Calderon Cardenas, German y Ortiz Lopez, Rocio y Rivas Estilla, Ana M y Ancer Rodriguez, Jesus y Rojas Martinez, Augusto (2010) Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer, 10 (1). ISSN 1471-2407

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Background: Several viruses with known oncogenic potential infect prostate tissue, among these are the polyomaviruses BKV, JCV, and SV40; human papillomaviruses (HPVs), and human cytomegalovirus (HCMV) infections. Recently, the Xenotropic Murine Leukemia Virus-related gammaretrovirus (XMRV) was identified in prostate tissue with a high prevalence observed in prostate cancer (PC) patients homozygous for the glutamine variant of the RNASEL protein (462Q/Q). Association studies with the R462Q allele and non-XMRV viruses have not been reported. We assessed associations between prostate cancer, prostate viral infections, and the RNASEL 462Q allele in Mexican cancer patients and controls. Methods: 130 subjects (55 prostate cancer cases and 75 controls) were enrolled in the study. DNA and RNA isolated from prostate tissues were screened for the presence of viral genomes. Genotyping of the RNASEL R462Q variant was performed by Taqman method. Results: R/R, R/Q, and Q/Q frequencies for R462Q were 0.62, 0.38, and 0.0 for PC cases and 0.69, 0.24, and 0.07 for controls, respectively. HPV sequences were detected in 11 (20.0%) cases and 4 (5.3%) controls. XMRV and HCMV infections were detected in one and six control samples, respectively. The risk of PC was significantly increased (Odds Ratio = 3.98; 95% CI: 1.17-13.56, p = 0.027) by infection of the prostatic tissue with HPV. BKV, JCV, and SV40 sequences were not detected in any of the tissue samples examined. Conclusions: We report a positive association between PC and HPV infection. The 462Q/Q RNASEL genotype was not represented in our PC cases; thus, its interaction with prostate viral infections and cancer could not be evaluated.

Tipo de elemento: Article
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Martinez Fierro, Margarita LNO ESPECIFICADONO ESPECIFICADO
Leach, Robin JNO ESPECIFICADONO ESPECIFICADO
Gomez Guerra, Lauro SNO ESPECIFICADONO ESPECIFICADO
Garza Guajardo, RaquelNO ESPECIFICADONO ESPECIFICADO
Johnson Pais, TeresaNO ESPECIFICADONO ESPECIFICADO
Beuten, JokeNO ESPECIFICADONO ESPECIFICADO
Morales Rodríguez, Idelma BereniseNO ESPECIFICADONO ESPECIFICADO
Hernandez Ordoñez, Mario ANO ESPECIFICADONO ESPECIFICADO
Calderon Cardenas, GermanNO ESPECIFICADONO ESPECIFICADO
Ortiz Lopez, RocioNO ESPECIFICADONO ESPECIFICADO
Rivas Estilla, Ana MNO ESPECIFICADONO ESPECIFICADO
Ancer Rodriguez, JesusNO ESPECIFICADONO ESPECIFICADO
Rojas Martinez, AugustoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 29 Abr 2019 18:44
Última modificación: 21 Jun 2019 08:58
URI: http://eprints.uanl.mx/id/eprint/15082

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