Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics

Larenas Linnemann, Désirée y Michels, Alexandra y Dinger, Hanna y Shah Hosseini, Kijawasch y Mösges, Ralph y Arias Cruz, Alfredo y Ambriz Moreno, Marichuy y Barajas, Martín y Javier, Ruth y de la Luz Cid del Prado, María y Moreno, Manuel Alejandro y Almaráz, Roberto y García Cobas, Cecilia Y. y Garcia Imperial, Daniel A. y Muñoz, Rosa y Hernández Colín, Dante y Linares Zapien, Francisco J. y Luna Pech, Jorge A. y Matta Campos, Juan José y Jiménez, Norma y Medina Ávalos, Miguel Alejandro y Hernández, Alejandra y Maldonado, Alberto y López, Doris N. y Pizano Nazara, Luis J. y Sanchez, Emmanuel y Ramos López, José D. y Rodríguez Pérez, Noel y Rodríguez Ortiz, Pablo Gabriel (2014) Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics. Clinical and Translational Allergy, 4 (1). p. 20. ISSN 2045-7022

[img]
Vista previa
Texto
243.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (2MB) | Vista previa
URL o página oficial: http://doi.org/10.1186/2045-7022-4-20

Resumen

Background: Allergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate to AR phenotypes or age. Methods: In a national, cross-sectional study AR patients (2-70 y) seen by allergists underwent blinded skin prick testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes. Results: 628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Patients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermittent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p < 0.05) and grass pollen sensitization (p < 0.01). HDM sensitization was more frequent in children (0-11 y) and adolescents (12-17 y) (subtropical region: p < 0.0005; tropical region p < 0.05), but pollen sensitization becomes more important in the adult patients visiting allergists (Adults vs children + adolescents for tree pollen: p < 0.0001, weeds: p < 0.0005). Conclusions: In a country with (sub)tropical climate zones SPT sensitization patterns varied according to climatological zones; they were different from those found in Europe, HDM sensitization far outweighing pollen allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen sensitization was related to SAR, but no relation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens –some region specific- cover the majority of sensitizations in (sub)tropical climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries.

Tipo de elemento: Article
Palabras claves no controlados: House dust mite; Pollen; Skin prick test; Allergic sensitization; Allergic rhinitis; Intermittent rhinitis; Persistent rhinitis; Seasonal; Perennial
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Larenas Linnemann, DésiréeNO ESPECIFICADONO ESPECIFICADO
Michels, AlexandraNO ESPECIFICADONO ESPECIFICADO
Dinger, HannaNO ESPECIFICADONO ESPECIFICADO
Shah Hosseini, KijawaschNO ESPECIFICADONO ESPECIFICADO
Mösges, RalphNO ESPECIFICADONO ESPECIFICADO
Arias Cruz, AlfredoNO ESPECIFICADONO ESPECIFICADO
Ambriz Moreno, MarichuyNO ESPECIFICADONO ESPECIFICADO
Barajas, MartínNO ESPECIFICADONO ESPECIFICADO
Javier, RuthNO ESPECIFICADONO ESPECIFICADO
de la Luz Cid del Prado, MaríaNO ESPECIFICADONO ESPECIFICADO
Moreno, Manuel AlejandroNO ESPECIFICADONO ESPECIFICADO
Almaráz, RobertoNO ESPECIFICADONO ESPECIFICADO
García Cobas, Cecilia Y.NO ESPECIFICADONO ESPECIFICADO
Garcia Imperial, Daniel A.NO ESPECIFICADONO ESPECIFICADO
Muñoz, RosaNO ESPECIFICADONO ESPECIFICADO
Hernández Colín, DanteNO ESPECIFICADONO ESPECIFICADO
Linares Zapien, Francisco J.NO ESPECIFICADONO ESPECIFICADO
Luna Pech, Jorge A.NO ESPECIFICADONO ESPECIFICADO
Matta Campos, Juan JoséNO ESPECIFICADOorcid.org/0000-0002-0897-2790
Jiménez, NormaNO ESPECIFICADONO ESPECIFICADO
Medina Ávalos, Miguel AlejandroNO ESPECIFICADONO ESPECIFICADO
Hernández, AlejandraNO ESPECIFICADONO ESPECIFICADO
Maldonado, AlbertoNO ESPECIFICADONO ESPECIFICADO
López, Doris N.NO ESPECIFICADONO ESPECIFICADO
Pizano Nazara, Luis J.NO ESPECIFICADONO ESPECIFICADO
Sanchez, EmmanuelNO ESPECIFICADONO ESPECIFICADO
Ramos López, José D.NO ESPECIFICADONO ESPECIFICADO
Rodríguez Pérez, NoelNO ESPECIFICADONO ESPECIFICADO
Rodríguez Ortiz, Pablo GabrielNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 29 Mar 2019 21:39
Última modificación: 26 Mayo 2020 15:28
URI: http://eprints.uanl.mx/id/eprint/15132

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year