Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis

García Compeán, Diego y Jáquez Quintana, Joel Omar y Lavalle González, Fernando Javier y González González, José Alberto y Muñoz Espinosa, Linda Elsa y Villarreal Pérez, Jesús Zacarías y Maldonado Garza, Héctor Jesús (2014) Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis. World Journal of Gastroenterology, 20 (22). p. 7011. ISSN 1007-9327

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AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were measured, and oral glucose tolerance test (OGTT) was performed. According to OGTT results two groups of patients were formed: those with normal glucose tolerance (NGT) and those with SAGT. Patients were followed every three months. The mean follow-up was 932 d (range of 180-1925). Survival was analyzed by the Kaplan-Meyer method, and predictive factors of death were analyzed using the Cox proportional hazard regression model. RESULTS: Of the included patients, 30 showed NGT and 70 SAGT. Groups were significantly different only in age, INR, FPI and HOMA2-IR. Patients with SAGT showed lower 5-year cumulated survival than NGT patients (31.7% vs 71.6%, P = 0.02). Differences in survival were significant only after 3 years of follow-up. SAGT, Child-Pugh B, and high Child-Pugh and Model for EndStage Liver Disease (MELD) scores were independent predictors of death. The causes of death in 90.3% of cases were due to complications related to liver disease. CONCLUSION: SAGT was associated with lower survival. SAGT, Child-Pugh B, and high Child-Pugh and MELD scores were independent negative predictors of survival.

Tipo de elemento: Article
Palabras claves no controlados: Diabetes mellitus; Liver cirrhosis; Oral glucose tolerance test; Survival; Glucose metabolism disorders
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
García Compeán, DiegoNO ESPECIFICADONO ESPECIFICADO
Jáquez Quintana, Joel OmarNO ESPECIFICADONO ESPECIFICADO
Lavalle González, Fernando JavierNO ESPECIFICADONO ESPECIFICADO
González González, José AlbertoNO ESPECIFICADONO ESPECIFICADO
Muñoz Espinosa, Linda ElsaNO ESPECIFICADONO ESPECIFICADO
Villarreal Pérez, Jesús ZacaríasNO ESPECIFICADONO ESPECIFICADO
Maldonado Garza, Héctor JesúsNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 15 Mar 2019 22:50
Última modificación: 27 Ago 2019 16:51
URI: http://eprints.uanl.mx/id/eprint/15224

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