Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México

Hernandez Escalante, Victor M. y Nava González, Edna Judith y Voruganti, Venkata Saroja y Kent, Jack W. y Haack, Karin y Laviada Molina, Hugo A. y Molina Segui, Fernanda y Gallegos Cabriales, Esther Carlota y López Alvarenga, Juan Carlos y Cole, Shelley A. y Mezzles, Marguerite J. y Comuzzie, Anthony G. y Bastarrachea, Raúl A. (2014) Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México. Frontiers in Genetics, 5. ISSN 1664-8021

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URL o página oficial: http://doi.org/10.3389/fgene.2014.00380

Resumen

The prevalence of type 2 diabetes (T2D) is rising rapidly and in Mexicans is ∼19%. T2D is affected by both environmental and genetic factors. Although specific genes have been implicated in T2D risk few of these findings are confirmed in studies of Mexican subjects. Our aim was to replicate associations of 39 single nucleotide polymorphisms (SNPs) from 10 genes with T2D-related phenotypes in a community-based Mexican cohort. Unrelated individuals (n = 259) living in southeastern Mexico were enrolled in the study based at the University of Yucatan School of Medicine in Merida. Phenotypes measured included anthropometric measurements, circulating levels of adipose tissue endocrine factors (leptin, adiponectin, pro-inflammatory cytokines), and insulin, glucose, and blood pressure. Association analyses were conducted by measured genotype analysis implemented in SOLAR, adapted for unrelated individuals. SNP Minor allele frequencies ranged from 2.2 to 48.6%. Nominal associations were found for CNR1, SLC30A8, GCK, and PCSK1 SNPs with systolic blood pressure, insulin and glucose, and for CNR1, SLC30A8, KCNJ11, and PCSK1 SNPs with adiponectin and leptin (p < 0.05). P-values greater than 0.0014 were considered significant. Association of SNPs rs10485170 of CNR1 and rs5215 of KCNJ11 with adiponectin and leptin, respectively, reached near significance (p = 0.002). Significant association (p = 0.001) was observed between plasma leptin and rs5219 of KCNJ11.

Tipo de elemento:

Article

Palabras claves no controlados:

Single Nucleotide Polymorphisms (SNP); Association analysis; Minor allele frequency; Type 2 diabetes; Obesity

Materias:

R Medicina > RC Medicina Interna, Psiquiatría, Neurología

Divisiones:

Salud Pública y Nutrición

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Hernandez Escalante, Victor M.	NO ESPECIFICADO	NO ESPECIFICADO
Nava González, Edna Judith	edna.navag@uanl.mx	orcid.org/0000-0001-8818-2600
Voruganti, Venkata Saroja	NO ESPECIFICADO	NO ESPECIFICADO
Kent, Jack W.	NO ESPECIFICADO	NO ESPECIFICADO
Haack, Karin	NO ESPECIFICADO	NO ESPECIFICADO
Laviada Molina, Hugo A.	NO ESPECIFICADO	NO ESPECIFICADO
Molina Segui, Fernanda	NO ESPECIFICADO	NO ESPECIFICADO
Gallegos Cabriales, Esther Carlota	esther.gallegoscb@uanl.edu.mx	orcid.org/0000-0003-3619-2596
López Alvarenga, Juan Carlos	NO ESPECIFICADO	NO ESPECIFICADO
Cole, Shelley A.	NO ESPECIFICADO	NO ESPECIFICADO
Mezzles, Marguerite J.	NO ESPECIFICADO	NO ESPECIFICADO
Comuzzie, Anthony G.	NO ESPECIFICADO	NO ESPECIFICADO
Bastarrachea, Raúl A.	NO ESPECIFICADO	NO ESPECIFICADO