Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design
Bastarrachea, Raúl A. y Laviada Molina, Hugo A. y Nava González, Edna Judith y Leal Berumen, Irene y Escudero Lourdes, Claudia y Escalante Araiza, Fabiola y Peschard, Vanessa Giselle y Veloz Garza, Rosa A. y Haack, Karin y Martínez Hernández, Angélica y Barajas Olmos, Francisco M. y Molina Segui, Fernanda y Buenfil Rello, Fatima A. y Gonzalez Ramirez, Lucia y Janssen Aguilar, Reinhard y Lopez Muñoz, Ricardo y Perez Cetina, Fernanda y Gaytan Saucedo, Janeth F. y Vaquera, Zoila y Cornejo Barrera, Judith y Castillo Pineda, Juan Carlos y Murillo Ramirez, Areli y Diaz Tena, Sara P. y Figueroa Nuñez, Benigno y González López, Laura y Salinas Osornio, Rocío A. y Valencia Rendón, Melesio E. y Ángeles Chimal, José y Santa Olalla Tapia, Jesús y Remes Troche, José M. y Valdovinos Chávez, Salvador B. y Huerta Ávila, Eira E. y Han, Xianlin y Orozco, Lorena y Rodríguez Ayala, Ernesto y Weintraub, Susan y Gallegos Cabriales, Esther Carlota y Cole, Shelley A. y Kent, Jr., Jack W. (2018) Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design. Genes, 9 (11). pp. 1-16. ISSN 2073-4425
|
Texto
50.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Vista previa |
Resumen
Abstract: Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be due to variation in thecapacitytomanageanutritionalload. Weexaminedthegenomicbasisofpostprandialmetabolism. Our main purpose was to introduce the GEMM Family Study (Genetics of Metabolic Diseases in Mexico) as a multi-center study carrying out an ongoing recruitment of healthy urban adults. Each participant received a mixed meal challenge and provided a 5-hours’ time course series of blood, buffy coat specimens for DNA isolation, and adipose tissue (ADT)/skeletal muscle (SKM) biopsies at fasting and 3 h after the meal. A comprehensive profiling, including metabolomic signatures in blood and transcriptomic and proteomic profiling in SKM and ADT, was performed to describe tendencies for variation in postprandial response. Our data generation methods showed preliminary trends indicating that by characterizing the dynamic properties of biomarkers with metabolic activity and analyzing multi-OMICS data it could be possible, with this methodology and research design, to identify early trends for molecular biology systems and genes involved in the fasted and fed states.
Tipo de elemento: | Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Divisiones: | Salud Pública y Nutrición | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Usuario depositante: | Lic. Josimar Pulido | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Creadores: |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fecha del depósito: | 26 Ago 2020 22:28 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Última modificación: | 07 Dic 2021 20:21 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/15977 |
Actions (login required)
![]() |
Ver elemento |