Phenolic Compounds in Organic and Aqueous Extracts from Acacia farnesiana Pods Analyzed by ULPS-ESI-Q-oa/TOF-MS. In Vitro Antioxidant Activity and Anti-Inflammatory Response in CD-1 Mice
Delgadillo Puga, Claudia y Cuchillo Hilario, Mario y Navarro Ocaña, Arturo y Medina Campos, Omar Noel y Nieto Camacho, Antonio y Ramírez Apan, Teresa y López Tecpoyotl, Zenón Gerardo y Díaz Martínez, Margarita y Alvarez Izazaga, Marsela Alejandra y Cruz Martínez, Yessica Rosalina y Sánchez Quezada, Vanessa y Gómez, Francisco Enrique y Torre Villalvazo, Iván y Furuzawa Carballeda, Janette y Camacho Corona, María del Rayo y Pedraza Chaverri, José (2018) Phenolic Compounds in Organic and Aqueous Extracts from Acacia farnesiana Pods Analyzed by ULPS-ESI-Q-oa/TOF-MS. In Vitro Antioxidant Activity and Anti-Inflammatory Response in CD-1 Mice. Molecules, 23 (9). pp. 1-21. ISSN 1420-3049
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Abstract: Background: Acaciafarnesiana (AF) pods have been traditionally used to treat dyspepsia, diarrhea and topically for dermal inflammation. Main objectives: (1) investigate the antioxidant activity and protection against oxidative-induced damage of six extracts from AF pods and (2) their capacitytocurbtheinflammationprocessaswellastodown-regulatethepro-inflammatorymediators. Methods: Five organic extracts (chloroformic, hexanic, ketonic, methanolic, methanolic:aqueous and one aqueous extract) were obtained and analyzed by UPLC-ESI-Q-oa/TOF-MS. Antioxidant activity (DPPH•, ORAC and FRAP assays) and lipid peroxidation (TBARS assay) were performed. Assessmentofanti-inflammatorypropertieswasmadebytheearedemainducedmodelinCD-1mice andMPOactivityassay. Likewise,histologicalanalysis,IL-1β,IL-6,IL-10,TNF-α,COXmeasurements plus nitrite and immunohistochemistry analysis were carried out. Results: Methyl gallate, gallic acid,galloyl glucose isomer 1, galloyl glucose isomer 2, galloyl glucose isomer 3, digalloyl glucose isomer 1, digalloyl glucose isomer 2, digalloyl glucose isomer 3, digalloyl glucose isomer 4, hydroxytyrosol acetate, quinic acid, and caffeoylmalic acid were identified. Both organic and aqueous extracts displayed antioxidant activity. All extracts exhibited a positive effect on the interleukins, COX and immunohistochemistry assays. Conclusion: All AF pod extracts can be effective as antioxidant and topical anti-inflammatory agents. Keywords: Acacia farnesiana pods; antioxidant and anti-inflammatory activities; bioactive compounds; polyphenols
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Materias: | Q Ciencia > QD Química | |||||||||||||||||||||||||||||||||||||||||||||||||||
Divisiones: | Ciencias Químicas | |||||||||||||||||||||||||||||||||||||||||||||||||||
Usuario depositante: | Lic. Josimar Pulido | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Fecha del depósito: | 25 Jun 2020 16:32 | |||||||||||||||||||||||||||||||||||||||||||||||||||
Última modificación: | 05 Mar 2024 20:10 | |||||||||||||||||||||||||||||||||||||||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/16096 |
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