Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

Vázquez Guillén, José Manuel y Palacios Saucedo, Gerardo del Carmen y Rivera Morales, Lydia Guadalupe y Alonzo Morado, Monica Valeria y Burciaga Bernal, Saira Berenice y Montufar Martínez, Maribel y Ortiz López, Rocío y González Villasana, Vianey y Martínez Torres, Ana Carolina y Serna Hernández, Julio César y Hernández Martínez, Silvia Judith y Castelán Maldonado, Edmundo Erbey y Zavala Pompa, Ángel y Montalvo Bañuelos, Martha Socorro y García Cabello, Ricardo y Sánchez Fresno, Ethel Corinthia y Rodríguez Padilla, Cristina (2018) Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study. PeerJ, 6. pp. 1-17. ISSN 2167-8359

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URL o página oficial: http://doi.org/10.7717/peerj.5834

Resumen

Background. Human papillomavirus (HPV) is recognized as an important risk factor for laryngeal carcinogenesis. Although HPV-16 and 18 have been strongly implicated, the presence of other high-risk HPV (HR-HPV) genotypes or the coinfection with Epstein-Barr virus (EBV) or Merkel cell polyomavirus (MCPV) may increase the risk, but their etiological association has not been definitively established. Methods. We characterized the genotype-specific HPV and the frequency of EBV and MCPV infections through the detection of their DNA in 195 laryngeal specimens of squamous cell carcinoma (SCC) histologically confirmed. Results. HPV DNA was detected in 93 (47.7%) specimens. HPV-11 was the most frequent with 68 cases (73.1%), and HPV-52 was the most frequently HR-HPV found with 51 cases, which corresponds to 54.8% of all HPV-positive specimens. EBV DNA was detected in 54 (27.7%) tumor tissue specimens of which 25 (46.3%) were in coinfection with HPV. MCPV DNA was detected only in 11 (5.6%) cases of which 5 (45.4%) were in coinfection with an HR-HPV. No association between the presence of DNA of the three examined viruses and the patient smoking habits, alcohol consumption, age, the keratinization status, differentiation grade, or localization of the tumor in the larynx were found. Discussion. HPV-52 was the most prevalent HR-HPV, which may suggest that this and other genotypes in addition to HPV-16 and 18 could be considered for prophylaxis. However, further studies including non-cancer larynx cases and the evaluation of other molecular markers and viral co-infection mechanisms are needed to determine the role of the different HR-HPV genotypes, EBV, and MCPV in the etiology of SCC of the larynx.

Tipo de elemento: Article
Materias: Q Ciencia > QR Microbiología
Divisiones: Centro de Investigación y Desarrollo en Ciencias de la Salud
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Vázquez Guillén, José ManuelNO ESPECIFICADONO ESPECIFICADO
Palacios Saucedo, Gerardo del CarmenNO ESPECIFICADONO ESPECIFICADO
Rivera Morales, Lydia GuadalupeNO ESPECIFICADONO ESPECIFICADO
Alonzo Morado, Monica ValeriaNO ESPECIFICADONO ESPECIFICADO
Burciaga Bernal, Saira BereniceNO ESPECIFICADONO ESPECIFICADO
Montufar Martínez, MaribelNO ESPECIFICADONO ESPECIFICADO
Ortiz López, RocíoNO ESPECIFICADONO ESPECIFICADO
González Villasana, VianeyNO ESPECIFICADONO ESPECIFICADO
Martínez Torres, Ana CarolinaNO ESPECIFICADONO ESPECIFICADO
Serna Hernández, Julio CésarNO ESPECIFICADONO ESPECIFICADO
Hernández Martínez, Silvia JudithNO ESPECIFICADONO ESPECIFICADO
Castelán Maldonado, Edmundo ErbeyNO ESPECIFICADONO ESPECIFICADO
Zavala Pompa, ÁngelNO ESPECIFICADONO ESPECIFICADO
Montalvo Bañuelos, Martha SocorroNO ESPECIFICADONO ESPECIFICADO
García Cabello, RicardoNO ESPECIFICADONO ESPECIFICADO
Sánchez Fresno, Ethel CorinthiaNO ESPECIFICADONO ESPECIFICADO
Rodríguez Padilla, CristinaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 29 Ago 2019 20:45
Última modificación: 29 Mayo 2020 18:21
URI: http://eprints.uanl.mx/id/eprint/16601

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