DNA damage in acute myeloid leukemia patients of Northern Mexico

Dávila Rodríguez, Martha Imelda y Cortes Gutiérrez, Elva Irene y Hernández Valdés, Roberto y Guzmán Cortés, Karla y De León Cantú, Rosa E. y Cerda Flores, Ricardo Martín y Báez De la Fuente, Enrique (2017) DNA damage in acute myeloid leukemia patients of Northern Mexico. European Journal of Histochemistry, 61 (4). pp. 295-298. ISSN 1121-760X

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URL o página oficial: http://doi.org/10.4081/ejh.2017.2851

Resumen

Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

Tipo de elemento: Article
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Dávila Rodríguez, Martha ImeldaNO ESPECIFICADONO ESPECIFICADO
Cortes Gutiérrez, Elva IreneNO ESPECIFICADONO ESPECIFICADO
Hernández Valdés, RobertoNO ESPECIFICADONO ESPECIFICADO
Guzmán Cortés, KarlaNO ESPECIFICADONO ESPECIFICADO
De León Cantú, Rosa E.NO ESPECIFICADONO ESPECIFICADO
Cerda Flores, Ricardo MartínNO ESPECIFICADONO ESPECIFICADO
Báez De la Fuente, EnriqueNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 01 Mayo 2020 15:55
Última modificación: 08 Mayo 2020 15:39
URI: http://eprints.uanl.mx/id/eprint/17430

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