DNA damage in acute myeloid leukemia patients of Northern Mexico

Dávila Rodríguez, Martha Imelda y Cortés Gutiérrez, Elva Irene y Hernández Valdés, Roberto y Guzmán Cortés, Karla y De León Cantú, Rosa E. y Cerda Flores, Ricardo Martín y Báez de la Fuente, Enrique (2017) DNA damage in acute myeloid leukemia patients of Northern Mexico. European Journal of Histochemistry, 61 (4). pp. 295-298. ISSN 1121-760X

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Resumen

Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

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