Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013

Swerdlow, David L. y Canche Pech, Jose Reyes y Conde Ferraez, Laura y Puerto Solis, Marylin y Gonzalez Losa, Refugio y Granja Pérez, Pilar y Villanueva Jorge, Salha y Chan Gasca, Maria y Gómez Carballo, Jesus y López Ochoa, Luisa y Jiménez Delgadillo, Bertha y Rodríguez Sánchez, Iram y Ramírez Prado, Jorge y Ayora Talavera, Guadalupe (2017) Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. PLOS ONE, 12 (12). pp. 1-17. ISSN 1932-6203

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Abstract The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N1)pdm09 virus throughout the year. We have characterized the molecular composition of the Hemagglutinin (HA) and Neuraminidase (NA) genes of the A(H1N1)pdm09 virus from both epidemic seasons, emphasizing the genetic characteristics of viruses isolated from Yucatan in Southern Mexico. The molecular analysis of viruses from the 2012 revealed that all viruses from Mexico were predominantly grouped in clade 7. Strikingly, the molecular characterization of viruses from 2013 revealed that viruses circulating in Yucatan were genetically different to viruses from other regions of Mexico. In fact, we identified the occurrence of two genetic variants containing relevant mutations at both the HA and NA surface antigens. There was a difference on the temporal circulation of each genetic variant, viruses containing the mutations HA-A141T / NA-N341S were detected in May, June and July; whereas viruses containing the mutations HA-S162I / NAL206S circulated in August and September. We discuss the significance of these novel genetic changes.

Tipo de elemento: Article
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Swerdlow, David L.NO ESPECIFICADONO ESPECIFICADO
Canche Pech, Jose ReyesNO ESPECIFICADONO ESPECIFICADO
Conde Ferraez, LauraNO ESPECIFICADONO ESPECIFICADO
Puerto Solis, MarylinNO ESPECIFICADONO ESPECIFICADO
Gonzalez Losa, RefugioNO ESPECIFICADONO ESPECIFICADO
Granja Pérez, PilarNO ESPECIFICADONO ESPECIFICADO
Villanueva Jorge, SalhaNO ESPECIFICADONO ESPECIFICADO
Chan Gasca, MariaNO ESPECIFICADONO ESPECIFICADO
Gómez Carballo, JesusNO ESPECIFICADONO ESPECIFICADO
López Ochoa, LuisaNO ESPECIFICADONO ESPECIFICADO
Jiménez Delgadillo, BerthaNO ESPECIFICADONO ESPECIFICADO
Rodríguez Sánchez, IramNO ESPECIFICADONO ESPECIFICADO
Ramírez Prado, JorgeNO ESPECIFICADONO ESPECIFICADO
Ayora Talavera, GuadalupeNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 01 Mayo 2020 15:52
Última modificación: 01 Mayo 2020 15:52
URI: http://eprints.uanl.mx/id/eprint/17476

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