Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era

Nava González, Edna Judith y Gallegos Cabriales, Esther Carlota y Leal Berumen, Irene y Bastarrachea, Raúl A. (2017) Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era. International Journal of Environmental Research and Public Health, 14 (9). pp. 1-11. ISSN 1660-4601

Vista previa

Texto 332.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Vista previa

Resumen

Abstract: Studies of gene-environment (GxE) interactions describe how genetic and environmental factors influence the risk of developing disease. Intermediate (molecular or clinical) phenotypes (IPs) are traits or metabolic biomarkers that mediate the effects of gene-environment influences on risk behaviors. Functional systems genomics discovery offers mechanistic insights into how DNA variations affect IPs in order to detect genetic causality for a given disease. Disorders of body compositionincludeobesity(OB),Type2diabetes(T2D),andosteoporosis(OSTP).Thesepathologies are examples of how a GxE interaction contributes to their development. IPs as surrogates for inherited genotypes play a key role in models of genetic and environmental interactions in health outcomes. Such predictive models may unravel relevant genomic and molecular pathways for preventive and therapeutic interventions for OB, T2D, and OSTP. Annotation strategies for genomes, in contrast to phenomes, are well advanced. They generally do not measure specific aspects of the environment. Therefore, the concepts of deep phenotyping and the exposome generate new avenues to exploit with high-resolution technologies for analyzing this sophisticated phenome. With the successful characterization of phenomes, exposomes, and genomes, environmental and geneticdeterminantsofchronicdiseasescanbeunitedwithmulti-OMICSstudiesthatbetterexamine GxE interactions. Keywords: GxE interactions; intermediate phenotypes; OMICS; diabetes; obesity; osteoporosis; phenome; exposome

Actions (login required)

Ver elemento