![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma
Martínez Pérez, Fernando y García Cuellar, Claudia María y Hernández Delgadillo, René y Zaragoza Magaña, Valentín y Sánchez Pérez, Yesennia y Meester, Irene y Nakagoshi Cepeda, Sergio Eduardo y Solís Soto, Juan Manuel y Nakagoshi Cepeda, María Argelia Akemi y Chellam, Shankararaman y Cabral Romero, Claudio (2019) Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma. Journal of Nanomaterials, 2019. pp. 1-8. ISSN 1687-4110
|
Texto
23471.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (3MB) | Vista previa |
Resumen
The objective of this study was to compare the antitumor activity of lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine (CHX) on human squamous cell carcinoma. BisBAL NPs were synthesized by colloidal method and characterized by energy dispersive X-ray spectroscopy in conjunction with scanning electron microscopy (EDS-SEM). The effect of BisBAL NPs and CHX on oral cancer cell line (CAL-27) and nontumor control cell human gingival fibroblasts (HGFs) was determined by MTT cell viability assay. The obtained results showed selective inhibition of CAL-27 cell growth by BisBAL nanoclusters. A 24 h exposition to 25 μM BisBAL NP decreased 91% of CAL-27 cell growth, while nontumor HGFs cells were unaffected by BisBAL NPs showing 90% of cell viability. In contrast, CHX kills both CAL-27 and HGFs with the same efficacy. 25 μM of CHX decreased 97% and 80% of tumor and nontumoral cell growth. BisBAL NP and CHX alter cell permeability suggesting that action mechanism may include loss of cell membrane integrity. Also, CHX and not BisBAL NP presented genotoxicity on genomic DNA of tumor cells. As conclusion, BisBAL NPs have a selective antitumor activity on human squamous cell carcinoma, unlike CHX which was cytotoxic for both tumoral and nontumoral control cells.
| Tipo de elemento: | Article | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Materias: | R Medicina > RK Odontología | ||||||||||||||||||||||||||||||||||||
| Divisiones: | Odontología | ||||||||||||||||||||||||||||||||||||
| Usuario depositante: | Editor Repositorio | ||||||||||||||||||||||||||||||||||||
| Creadores: |
|
||||||||||||||||||||||||||||||||||||
| Fecha del depósito: | 24 Jun 2022 20:19 | ||||||||||||||||||||||||||||||||||||
| Última modificación: | 24 Jun 2022 20:19 | ||||||||||||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/23471 |
orcid.org/0000-0001-6799-1943Actions (login required)
 |
Ver elemento |
Descargar estadísticas
Descargar estadísticas
