In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants

Rodríguez Garza, Nancy Edith y Quintanilla Licea, Ramiro y Romo Sáenz, César Iván y Tamez Guerra, Patricia y Rodríguez Padilla, Cristina y Gómez Flores, Ricardo Alberto (2023) In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants. Life.

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URL o página oficial: https://www.mdpi.com/2075-1729/13/4/958

Resumen

Cancer is a major health problem with significant morbidity and mortality. In addition, plants are a source of metabolites with diverse biological properties, including antitumor potential. In this study, we investigated the in vitro murine lymphoma L5178Y-R cell growth inhibition, human peripheral blood mononuclear cells (PBMC) toxicity and proliferation, and antioxidant, hemolytic, and anti-hemolytic activities of methanol extracts from 15 plants of traditional use in Mexico. Justicia spicigera caused the highest tumor cell growth inhibition with a half maximal inhibitory concentration (IC50) of 29.10 ug/mL and a selectivity index >34.36 compared with those of PBMC, whereas Mimosa tenuiflora showed the highest lymphoproliferative activity from 200 ug/mL compared with that induced by concanavalin A. In addition, M. tenuiflora showed an antioxidant effect (IC50 = 2.86 ug/mL) higher than that of ascorbic acid. Regarding the hemolytic and anti-hemolytic activity, all extracts presented significant anti-hemolytic activity. The extract of J. spicigera is emerging as a possible source of effective antineoplastic compounds.

Tipo de elemento:

Article

Materias:

Q Ciencia > QH Historia Natural, Biología

Usuario depositante:

MC Nancy Edith Rodríguez Garza

Creadores:

Creador	Email	ORCID
Rodríguez Garza, Nancy Edith	nancy.rodriguezgrz@uanl.edu.mx	orcid.org/0000-0003-3201-5437
Quintanilla Licea, Ramiro	ramiro.quintanillalc@uanl.edu.mx	orcid.org/0000-0002-4379-6913
Romo Sáenz, César Iván	NO ESPECIFICADO	NO ESPECIFICADO
Tamez Guerra, Patricia	NO ESPECIFICADO	orcid.org/0000-0002-4831-2340
Rodríguez Padilla, Cristina	cristina.rodriguezpd@uanl.edu.mx	orcid.org/0000-0001-5469-8449
Gómez Flores, Ricardo Alberto	ricardo.gomezfl@uanl.edu.mx	NO ESPECIFICADO