Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents

Domínguez Vigil, Irma G. y Mata Cárdenas, Benito D. y Esquivel Ferriño, Patricia C. y Avalos Alanís, Francisco G. y Vargas Villarreal, Javier y Camacho Corona, María del Rayo (2022) Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents. Plants, 11 (17). pp. 1-7. ISSN 2223-7747

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Resumen

Abstract: Foeniculum vulgare is used for the treatment of diarrhea in Mexican traditional medicine. Hexane extract showed 94 % inhibition of Giardia duodenalis trophozoites at 300 µg/mL. Therefore, 20 constituents of hexane extract were evaluated to determine their antigiardial activity. Interestingly, six compounds showed good activity toward the parasite. These compounds were (1R,4S) (+)-Camphene (61%), (R)(−)-Carvone (66%), estragole (49%), p-anisaldehyde (67%), 1,3-benzenediol (56%), and trans, trans-2,4-undecadienal (97%). The aldehyde trans, trans-2,4-undecadienal was the most active compound with an IC50 value of 72.11 µg/mL against G. duodenalistrophozoites. This aldehyde was less toxic (IC50 588.8 µg/mL) than positive control metronidazole (IC50 83.5 µg/mL) against Vero cells. The above results could support the use of F. vulgare in Mexican traditional medicine.

Tipo de elemento:

Article

Palabras claves no controlados:

Hinojo común; Giardia duodenalis; Actividad antigiardial

Materias:

Q Ciencia > QD Química

Divisiones:

Ciencias Químicas > Maestría en Ciencias con orientación en Farmacia

Usuario depositante:

Dr Irma G Dominguez Vigil

Creadores:

Creador	Email	ORCID
Domínguez Vigil, Irma G.	irma52vigil@gmail.com	orcid.org/0000-0003-4687-6318
Mata Cárdenas, Benito D.	NO ESPECIFICADO	NO ESPECIFICADO
Esquivel Ferriño, Patricia C.	NO ESPECIFICADO	NO ESPECIFICADO
Avalos Alanís, Francisco G.	NO ESPECIFICADO	NO ESPECIFICADO
Vargas Villarreal, Javier	NO ESPECIFICADO	NO ESPECIFICADO
Camacho Corona, María del Rayo	maria.camachocn@uanl.edu.mx	NO ESPECIFICADO