Steroid 5 alpha-reductase 2 enzyme variants, biomass exposure and tobacco use in Mexican patients with prostate cancer

Delgado Balderas, Jesús R. y Gallardo Blanco, Hugo Leonid y Yee De León, Juan y Rivas Estilla, Ana y Soto García, Brenda y Araiz Hernández, Diana y Garza Guajardo, Raquel y Nañez Marín, Melissa y Hernández Barajas, David y García Bailón, Aldo Missael y Vizcarra Mata, Guillermo y Ocaña Munguía, Marco Alberto y Gómez Guerra, Lauro Salvador y Sánchez Domínguez, Celia Nohemí (2020) Steroid 5 alpha-reductase 2 enzyme variants, biomass exposure and tobacco use in Mexican patients with prostate cancer. Oncology Letters, 20 (5). p. 1. ISSN 1792-1074, 1792-1082

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Resumen

The presence of the genetic variants of the steroid 5‑alpha reductase 2 enzyme, which is encoded by the SRD5A2 gene, has been associated with an increased risk of developing prostate cancer among certain ethnic groups. However, these molecular studies have not been conducted on the Mexican population. The analysis of the genetic variants, rs9282858 and rs523349, was performed in 101 males with prostate cancer and 100 healthy controls classified as males without prostate abnormalities (n=60) and males with benign pros‑ tatic hyperplasia (n=40), to identify a probable association with this cancer type in the Northeast Mexican population. An association was identified between prostate cancer and biomass exposure [P=0.012; odds ratio (OR), 2.89; confidence interval (CI)=1.21‑6.88] and tobacco use (P=0.028; OR=1.88; CI=1.07‑3.31), while no association was observed between cancer development and the rs9282858 variant, or between a protective effect and the rs523349 variant. Notably, an associa‑tion was identified between rs523349 and biomass exposure (P=0.013, OR=3.17; CI=1.23‑8.17 for the G risk allele, and OR=0.32, CI=0.12‑0.81 for the C protective allele) using the dominant genetic model. To the best of our knowledge, the present study was the first of its type to investigate the Mexican population with prostate cancer.

Tipo de elemento:

Article

Palabras claves no controlados:

A49T (rs9282858), V89L (rs523349), Biomass exposure, Prostate cancer, Steroid 5 alpha-reductase 2 enzyme

Materias:

CONACYT > Biología y Química
CONACYT > Medicina y Ciencias de la Salud

Divisiones:

Medicina > Maestría en Ciencias con Orientación en Biología Molecular e Ingeniería Genética

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Delgado Balderas, Jesús R.	jrolandodelgadob@gmail.com	orcid.org/0000-0002-9016-2016
Gallardo Blanco, Hugo Leonid	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Yee De León, Juan	NO ESPECIFICADO	NO ESPECIFICADO
Rivas Estilla, Ana	NO ESPECIFICADO	NO ESPECIFICADO
Soto García, Brenda	NO ESPECIFICADO	NO ESPECIFICADO
Araiz Hernández, Diana	NO ESPECIFICADO	NO ESPECIFICADO
Garza Guajardo, Raquel	NO ESPECIFICADO	NO ESPECIFICADO
Nañez Marín, Melissa	NO ESPECIFICADO	NO ESPECIFICADO
Hernández Barajas, David	davidhdzb@hotmail.com	NO ESPECIFICADO
García Bailón, Aldo Missael	amgb_13@hotmail.com	orcid.org/0000-0001-6071-4978
Vizcarra Mata, Guillermo	NO ESPECIFICADO	NO ESPECIFICADO
Ocaña Munguía, Marco Alberto	mocana94@gmail.com	NO ESPECIFICADO
Gómez Guerra, Lauro Salvador	lauro.gomezgrr@uanl.edu.mx	NO ESPECIFICADO
Sánchez Domínguez, Celia Nohemí	celia.sanchezdm@uanl.edu.mx	orcid.org/0000-0002-3444-9565