Models of hepatoprotective activity assessment

Delgado Montemayor, Cecilia y Cordero Pérez, Paula y Salazar Aranda, Ricardo y Waksman Minsky, Noemí Herminia (2015) Models of hepatoprotective activity assessment. Medicina universitaria, 17 (69). pp. 222-228. ISSN 1665-5796

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Resumen

Liver diseases are a major health problem worldwide, making it necessary to develop new molecules that help counteract or prevent such diseases. On account of this fact, investigations aiming to obtain natural and/or synthetic compounds possessing hepatoprotective activity have been undertaken. The development of new drugs consists of a variety of steps, ranging from the discovery of the pharmacological effects in cellular and animal models, to finally demonstrate their efficacy and safety in humans. Different models for assessment of the hepatoprotective activity in vitro, ex vivo and in vivo can be found in medical literature. The purpose of this review is to show the features, main advantages and disadvantages of each of the models, the hepatotoxic agents most commonly used (CCl4, acetaminophen, ethanol, dgalactosamine, t-BuOOH, thioacetamide) as well as the biochemical parameters useful to assess liver damage in the different models.

Tipo de elemento: Article
Información adicional: Special thanks go to the Mexican National Council of Science and Technology (abbreviated CONACYT) for their support for the national scholarship no. 359832 and project no. 180997 of the Basic Scientific Research Grant 2012
Palabras claves no controlados: Hepatoprotection; In vitro models; In vivo models; Ex vivo models; Liver; Hepatocuration
Materias: Q Ciencia > QD Química
Divisiones: Medicina
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Delgado Montemayor, CeciliaNO ESPECIFICADONO ESPECIFICADO
Cordero Pérez, PaulaNO ESPECIFICADONO ESPECIFICADO
Salazar Aranda, Ricardoricardo.salazarar@uanl.edu.mxNO ESPECIFICADO
Waksman Minsky, Noemí HerminiaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 14 Nov 2016 20:39
Última modificación: 16 Ene 2017 20:38
URI: http://eprints.uanl.mx/id/eprint/11682

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