Staphylococcal Cassette Chromosome mec (SCCmec) in coagulase negative staphylococci

Martínez Meléndez, Julio Adrián y Morfín Otero, Rayo y Villarreal Treviño, Licet y González González, Gloria María y Llaca Díaz, Jorge Martín y Rodríguez Noriega, Eduardo y Camacho Ortiz, Adrián y Garza González, Elvira (2015) Staphylococcal Cassette Chromosome mec (SCCmec) in coagulase negative staphylococci. Medicina universitaria, 17 (69). pp. 229-233. ISSN 1665-5796

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Resumen

Coagulase-negative staphylococci (CoNS) are among the main causative agents of bacteremia. Staphylococcus epidermidis and Staphylococcus haemolyticus are the CoNS species most frequently isolated. These species are often associated with infections in immunocompromised patients who have a medical device implant. Methicillin resistance was first described in Staphylococcus aureus; it has also been reported in CoNS species. Methicillin resistance is conferred by expression of the mecA gene, contained within the staphylococcal cassette chromosome (SCCmec). mecA gene codes for the PBP2a protein which shows poor binding to beta-lactam antibiotics, so methicillin-resistant strains are resistant to beta-lactams. The presence of SCCmec in CoNS species complicates infections caused by these organisms, since it confers resistance to a variety of antibiotics, making treatment difficult. This review analyzes the clinical relevance of SCCmec as well as the diversity and structure of elements present in CoNS species.

Tipo de elemento:

Article

Materias:

Q Ciencia > QR Microbiología

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Martínez Meléndez, Julio Adrián	NO ESPECIFICADO	NO ESPECIFICADO
Morfín Otero, Rayo	NO ESPECIFICADO	NO ESPECIFICADO
Villarreal Treviño, Licet	NO ESPECIFICADO	NO ESPECIFICADO
González González, Gloria María	NO ESPECIFICADO	NO ESPECIFICADO
Llaca Díaz, Jorge Martín	jorgellaca@hotmail.com	orcid.org/0000-0001-6875-2530
Rodríguez Noriega, Eduardo	NO ESPECIFICADO	NO ESPECIFICADO
Camacho Ortiz, Adrián	NO ESPECIFICADO	NO ESPECIFICADO
Garza González, Elvira	NO ESPECIFICADO	NO ESPECIFICADO