Iron overload

Marfil Rivera, Luis Javier (2015) Iron overload. Medicina universitaria, 17 (69). pp. 240-242. ISSN 1665-5796

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Resumen

The normal iron content of the body is 3---4 g. It exists in hemoglobin, in iron-containing proteins different to hemoglobin, in iron bound to transferrin in plasma, and in the form of ferritin and hemosiderin. There is approximately 1 g of storage iron, mostly in liver, spleen, and bone marrow. Iron is lost in sweat, shed skin cells, and gastrointestinal loss at a rate of approximately 1 mg/day. Menstruating women lose an additional 0.5 mg/day to 1.0 mg/day of iron. Iron overload occurs when there is increased absorption of iron from a normal diet, or when the subject has received large doses of parenteral iron from multiple red cell transfusions or multiple infusions of intravenous iron.

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