Clinical characterization of acute and convalescent illness of confirmed chikungunya cases from Chiapas, S. Mexico: A cross sectional study

Roques, Pierre y Danis Lozano, Rogelio y Díaz González, Esteban Eduardo y Trujillo Murillo, Karina del Carmen y Caballero Sosa, Sandra y Sepúlveda Delgado, Jesús y Malo García, Iliana Rosalía y Canseco Ávila, Luis Miguel y Salgado Corsantes, Luis Manuel y Domínguez Arrevillaga, Sergio y Torres Zapata, Raúl y Gómez Cruz, Omar y Fernández Salas, Ildefonso (2017) Clinical characterization of acute and convalescent illness of confirmed chikungunya cases from Chiapas, S. Mexico: A cross sectional study. PLOS ONE, 12 (10). e0186923. ISSN 1932-6203

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Background The emerging chikungunya virus (CHIKV), is an arbovirus causing intense outbreaks in North America. The situation in Mexico is alarming, and CHIKV threatens to spread further throughout North America. Clinical and biological features of CHIKF outbreaks in Mexico have not been well described; thus, we conducted a cross sectional study of a CHIKV outbreak in Chiapas, Southern Mexico to further characterize these features. Methodology/Principal findings We collected blood samples from patients suspected of having chikungunya fever (CHIKF) who presented to Clinical Hospital ISSSTE Dr. Roberto Nettel in Tapachula, Chiapas, Mexico. In addition to the clinical examination, real-time polymerase chain reaction (PCR) standardized for the Asian Chikungunya lineage and/or enzyme-linked immunosorbent assay for immunoglobulin M (IgM) were used to confirm CHIKV diagnosis. Of a total of 850 patients who presented with probably CHIKV at Hospital “Dr. Roberto Nettel”, 112 probable CHIKF cases were enrolled in this study from November 2014- June 2015, of which 95 patients (84.8%) were CHIKV positive and 17 were negative (15.2%). Of these 95 CHIKV positive patients, 62 were positive by real-time reverse transcriptase PCR (+qRT-PCR); and 33 were seropositive to +IgM with a negative qRT-PCR. The most frequent symptoms reported were fever (100%), headache (82.3%), polyarthralgia (72.1%), and exanthem (82.3%). Biological abnormalities observed during CHIKV infection were lymphopenia (41.1%), leukopenia (51.6%), elevated transaminases (30.5%-46.3%) and high LDH (46.3%) and CRP (60.0%). Conclusion Clinical and biological data obtained from this study is providing more useful information for benchmarking purposes with outbreaks from different parts of the world and would be helpful for better patient care and treatment.

Tipo de elemento: Article
Materias: Q Ciencia > QH Historia Natural, Biología
Divisiones: Ciencias Biológicas
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Roques, PierreNO ESPECIFICADONO ESPECIFICADO
Danis Lozano, RogelioNO ESPECIFICADONO ESPECIFICADO
Díaz González, Esteban EduardoNO ESPECIFICADONO ESPECIFICADO
Trujillo Murillo, Karina del CarmenNO ESPECIFICADONO ESPECIFICADO
Caballero Sosa, SandraNO ESPECIFICADONO ESPECIFICADO
Sepúlveda Delgado, JesúsNO ESPECIFICADONO ESPECIFICADO
Malo García, Iliana RosalíaNO ESPECIFICADONO ESPECIFICADO
Canseco Ávila, Luis MiguelNO ESPECIFICADONO ESPECIFICADO
Salgado Corsantes, Luis ManuelNO ESPECIFICADONO ESPECIFICADO
Domínguez Arrevillaga, SergioNO ESPECIFICADONO ESPECIFICADO
Torres Zapata, RaúlNO ESPECIFICADONO ESPECIFICADO
Gómez Cruz, OmarNO ESPECIFICADONO ESPECIFICADO
Fernández Salas, IldefonsoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 22 Mayo 2020 17:00
Última modificación: 22 Mayo 2020 17:00
URI: http://eprints.uanl.mx/id/eprint/14506

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