Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

Cabral Romero, Claudio y Hernandez Delgadillo, Rene y Velasco Arias, y Martinez Sanmiguel, y Diaz, David y Zumeta Dubé, y Niño Arevalo, (2013) Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation. International Journal of Nanomedicine. p. 1645. ISSN 1178-2013

[img]
Vista previa
Texto
524.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Vista previa
URL o página oficial: http://doi.org/10.2147/IJN.S38708

Resumen

Abstract: Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85%) and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized aqueous colloidal Bi2 O3 nanoparticles.

Tipo de elemento: Article
Palabras claves no controlados: antimycotic agent, antifungal, cytotoxicity
Divisiones: Ciencias Biológicas
Odontología
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Cabral Romero, ClaudioNO ESPECIFICADONO ESPECIFICADO
Hernandez Delgadillo, ReneNO ESPECIFICADONO ESPECIFICADO
Velasco Arias, NO ESPECIFICADONO ESPECIFICADO
Martinez Sanmiguel, NO ESPECIFICADONO ESPECIFICADO
Diaz, DavidNO ESPECIFICADONO ESPECIFICADO
Zumeta Dubé, NO ESPECIFICADONO ESPECIFICADO
Niño Arevalo, NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 15 Sep 2020 12:36
Última modificación: 15 Sep 2020 12:36
URI: http://eprints.uanl.mx/id/eprint/14851

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year