In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil

Coronado Cerda, Erika Evangelina y Franco Molina, Moisés Armides y Mendoza Gamboa, Edgar y Prado García, Heriberto y Rivera Morales, Lydia Guadalupe y Zapata Benavides, Pablo y Rodríguez Salazar, María del Carmen y Caballero Hernández, Diana Elia y Tamez Guerra, Reyes Silvestre y Rodríguez Padilla, Cristina (2016) In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil. Journal of Immunology Research, 2016. pp. 1-10. ISSN 2314-8861

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URL o página oficial: http://doi.org/10.1155/2016/6942321

Resumen

Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP (ICRP) is an immunomodulatory compound that has antioxidants and anti-inflammatory effects. In order to investigate the chemoprotection effect of ICRP on bone marrow cells in 5-FU treated mice, total bone marrow (BM) cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM), cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed. Our results demonstrated that ICRP increased BM cell count and CFU-GM number, arrested BM cells in G0/G1 phase, increased the percentage of leukocyte, granulocytic, and erythroid populations, reduced ROS/superoxide formation and Nrf2 activation, and also improved hematological levels and weight gain in 5-FU treated mice. These results suggest that ICRP has a chemoprotective effect against 5-FU in BM cells that can be used in cancer patients.

Tipo de elemento: Article
Divisiones: Ciencias Biológicas
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Coronado Cerda, Erika EvangelinaNO ESPECIFICADONO ESPECIFICADO
Franco Molina, Moisés ArmidesNO ESPECIFICADONO ESPECIFICADO
Mendoza Gamboa, Edgaredgar.mendozagm@uanl.edu.mxorcid.org/0000-0002-0827-5717
Prado García, HeribertoNO ESPECIFICADONO ESPECIFICADO
Rivera Morales, Lydia GuadalupeNO ESPECIFICADONO ESPECIFICADO
Zapata Benavides, PabloNO ESPECIFICADONO ESPECIFICADO
Rodríguez Salazar, María del CarmenNO ESPECIFICADONO ESPECIFICADO
Caballero Hernández, Diana EliaNO ESPECIFICADONO ESPECIFICADO
Tamez Guerra, Reyes SilvestreNO ESPECIFICADONO ESPECIFICADO
Rodríguez Padilla, CristinaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 24 Mayo 2019 15:27
Última modificación: 24 Mayo 2019 15:27
URI: http://eprints.uanl.mx/id/eprint/14873

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