Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases

Duval, Florent y Cruz-Vega, Delia Elva y González Gamboa, Ivonne y González Garza y Barrón, María Teresa y Ponz, Fernando y Sánchez, Flora y Alarcón Galván, Gabriela y Moreno Cuevas, Jorge E. (2016) Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases. Disease Markers, 2016. pp. 1-7. ISSN 0278-0240

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URL o página oficial: http://doi.org/10.1155/2016/6597970

Resumen

There is a need for new noninvasive biomarkers (NIBMs) able to assess cholestasis and fibrosis in chronic cholestatic liver diseases (CCLDs). Tumorigenesis can arise from CCLDs. Therefore, autoantibodies to tumor-associated antigens (TAA) may be early produced in response to abnormal self-antigen expression caused by cholestatic injury. Vascular endothelial growth factor receptor3 (VEGFR-3) has TAA potential since it is involved in cholangiocytes and lymphatic vessels proliferations during CCLDs. This study aims to detect autoantibodies directed at VEGFR-3 during bile duct ligation- (BDL-) induced cholestatic injury in rat sera and investigate whether they could be associated with traditional markers of liver damage, cholestasis, and fibrosis. An ELISA was performed to detect anti-VEGFR-3 autoantibodies in sera of rats with different degree of liver injury and results were correlated with aminotransferases, total bilirubin, and the relative fibrotic area. Mean absorbances of anti-VEGFR-3 autoantibodies were significantly increased from week one to week five after BDL.The highest correlation was observed with total bilirubin (

Tipo de elemento: Article
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
R Medicina > RM Terapéutica, Farmacología
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Duval, FlorentNO ESPECIFICADONO ESPECIFICADO
Cruz-Vega, Delia ElvaNO ESPECIFICADONO ESPECIFICADO
González Gamboa, IvonneNO ESPECIFICADONO ESPECIFICADO
González Garza y Barrón, María TeresaNO ESPECIFICADONO ESPECIFICADO
Ponz, FernandoNO ESPECIFICADONO ESPECIFICADO
Sánchez, FloraNO ESPECIFICADONO ESPECIFICADO
Alarcón Galván, GabrielaNO ESPECIFICADONO ESPECIFICADO
Moreno Cuevas, Jorge E.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 08 Mayo 2020 13:17
Última modificación: 08 Mayo 2020 13:17
URI: http://eprints.uanl.mx/id/eprint/14881

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