Sperm chromatin dispersion by formaldehyde in Wistar rats

Betancourt Martínez, Nadia Denys y Jiménez Villarreal, J. y Carranza Rosales, María del Pilar y Guzmán Delgado, Nancy Elena y Leyva Orasma, C. y Viveros Valdez, José Ezequiel y Morán Martínez, Javier (2015) Sperm chromatin dispersion by formaldehyde in Wistar rats. Genetics and Molecular Research, 14 (3). pp. 10816-10826. ISSN 16765680

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Resumen

Formaldehyde (FA) is an environmental xenobiotic, which is genotoxic and carcinogenic to humans and animals; it induces DNA damage, mutations, and clastogenicity during critical cytogenetic events. FA-mediated oxidative stress is an important mechanism that has been associated with the induction of cytotoxic and genotoxic damage. Therefore, the objective of this study was to evaluate the dispersion of sperm chromatin and reproductive parameters induced by exposure to different concentrations of FA in Wistar rats. Compared to the percentage of sperm with fragmented DNA in the control group (18.10 ± 8.62%), the percentage of sperm with fragmented DNA increased following exposure to 5, 10, and 30 mg FA/kg body weight (29.60 ± 8.44, 85.20 ± 20.94 and 96.0 ± 7.87, respectively; P = 0.0001). Histopathological alterations were evident, especially in the seminiferous tubules. In conclusion, this study provides experimental evidence concerning the genotoxicity of FA, with particular reference to the decreased sperm concentration and motility and increased dispersion of DNA chromatin in rats.

Tipo de elemento: Article
Palabras claves no controlados: Formaldehyde, Sperm cells, Chromatin dispersion, Wistar rats, Histopathology
Divisiones: Ciencias Biológicas
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Betancourt Martínez, Nadia DenysNO ESPECIFICADONO ESPECIFICADO
Jiménez Villarreal, J.NO ESPECIFICADONO ESPECIFICADO
Carranza Rosales, María del PilarNO ESPECIFICADONO ESPECIFICADO
Guzmán Delgado, Nancy ElenaNO ESPECIFICADONO ESPECIFICADO
Leyva Orasma, C.NO ESPECIFICADONO ESPECIFICADO
Viveros Valdez, José Ezequieljose.viverosvld@uanl.edu.mxorcid.org/0000-0001-5944-7972
Morán Martínez, JavierNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 17 Mayo 2019 14:44
Última modificación: 29 Ago 2019 17:08
URI: http://eprints.uanl.mx/id/eprint/14945

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