Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis

Escarcena, Ricardo y Pérez Meseguer, Jonathan y Del Olmo, Esther y Alanís Garza, Blanca Alicia y Garza González, Elvira y Salazar Aranda, Ricardo y Waksman de Torres, Noemí (2015) Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis. Molecules, 20 (4). pp. 7245-7262. ISSN 1420-3049

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URL o página oficial: http://doi.org/10.3390/molecules20047245

Resumen

Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol.

Tipo de elemento:

Article

Palabras claves no controlados:

Serrulatane derivatives, Leubethanol, Semi-synthesis, In vitro antimycobacterial activity, Cytotoxicity assay

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Escarcena, Ricardo	NO ESPECIFICADO	NO ESPECIFICADO
Pérez Meseguer, Jonathan	NO ESPECIFICADO	NO ESPECIFICADO
Del Olmo, Esther	NO ESPECIFICADO	NO ESPECIFICADO
Alanís Garza, Blanca Alicia	NO ESPECIFICADO	NO ESPECIFICADO
Garza González, Elvira	NO ESPECIFICADO	NO ESPECIFICADO
Salazar Aranda, Ricardo	ricardo.salazarar@uanl.edu.mx	NO ESPECIFICADO
Waksman de Torres, Noemí	NO ESPECIFICADO	NO ESPECIFICADO