Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis

Escarcena, Ricardo y Pérez Meseguer, Jonathan y del Olmo, Esther y Alanís Garza, Blanca Alicia y Garza González, Elvira y Salazar Aranda, Ricardo y Waksman de Torres, Noemí (2015) Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis. Molecules, 20 (4). pp. 7245-7262. ISSN 1420-3049

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Resumen

Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol.

Tipo de elemento: Article
Palabras claves no controlados: Serrulatane derivatives, Leubethanol, Semi-synthesis, In vitro antimycobacterial activity, Cytotoxicity assay
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Escarcena, RicardoNO ESPECIFICADONO ESPECIFICADO
Pérez Meseguer, JonathanNO ESPECIFICADONO ESPECIFICADO
del Olmo, EstherNO ESPECIFICADONO ESPECIFICADO
Alanís Garza, Blanca AliciaNO ESPECIFICADONO ESPECIFICADO
Garza González, ElviraNO ESPECIFICADONO ESPECIFICADO
Salazar Aranda, Ricardoricardo.salazarar@uanl.edu.mxNO ESPECIFICADO
Waksman de Torres, NoemíNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 09 Mayo 2019 22:17
Última modificación: 09 Mayo 2019 22:17
URI: http://eprints.uanl.mx/id/eprint/14972

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