Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses

Tamez Perez, Hector Eloy y de Ossio, María Dolores Gómez y Quintanilla Flores, Dania Lizeth y Hernández Coria, Mayra Ivonne y Tamez Peña, Alejandra Lorena y Cuz Pérez, Gissén Jazmín y Proskauer Peña, Stephanie Lissette (2012) Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses. Revista da Associação Médica Brasileira, 58 (1). pp. 125-128. ISSN 01044230

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Objective: Methylprednisolone pulses are used in a variety of disease conditions, both for acute and chronic therapy. Although well tolerated, they increase glucose levels in both non-diabetic and diabetic patients. They may also be considered a significant risk for acute metabolic alterations. The purpose of this report is to determine the metabolic changes in blood glucose levels in non-diabetic patients receiving methylprednisolone pulses and identify the presence of predictive factors for its development. Methods: Observational, prospective study in 50 non-diabetic patients receiving 1 g intravenous methylprednisolone pulses for three consecutive days as an indication for diverse autoimmune disorders. Demographic, anthropometric, and metabolic variables were analyzed, and glucose, insulin and C-peptide levels after each steroid pulse were identified. Different variables and the magnitude of hyperglycemia were analyzed using Pearson’s correlation. Results: 50 patients were included, predominantly women (66%, n = 33). The average age was 41 ± 14 years with a BMI of 26 ± 3 kg/m2 . Baseline glucose was 83 ± 10 mg/dL. After each steroid pulse, glucose increased to 140 ± 28, 160 ± 38 and 183 ± 44, respectively (p <0.001). C-peptide and insulin concentrations increased significantly (p <0.001). The prevalence of fasting hyperglycemia after each pulse was 68%, 94% and 98%, respectively. We found no correlation between the magnitude of hyperglycemia and the studied variables. Conclusion: Methylprednisolone pulses produced significant increases in fasting glucose in most patients without diabetes. Further studies are needed to define its role in long-term consequences.

Tipo de elemento: Article
Palabras claves no controlados: Methylprednisolone; diabetes mellitus; hyperglycemia.
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Tamez Perez, Hector EloyNO ESPECIFICADONO ESPECIFICADO
de Ossio, María Dolores GómezNO ESPECIFICADONO ESPECIFICADO
Quintanilla Flores, Dania LizethNO ESPECIFICADONO ESPECIFICADO
Hernández Coria, Mayra IvonneNO ESPECIFICADONO ESPECIFICADO
Tamez Peña, Alejandra LorenaNO ESPECIFICADONO ESPECIFICADO
Cuz Pérez, Gissén JazmínNO ESPECIFICADONO ESPECIFICADO
Proskauer Peña, Stephanie LissetteNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 22 Mayo 2019 15:14
Última modificación: 25 Jun 2019 08:09
URI: http://eprints.uanl.mx/id/eprint/15038

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