An XMRV Derived Retroviral Vector as a Tool for Gene Transfer

Cervantes García, Daniel y Rojas Martínez, Augusto y Camerini, David (2011) An XMRV Derived Retroviral Vector as a Tool for Gene Transfer. Virology Journal, 8 (1). p. 284. ISSN 1743-422X

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Resumen

Background: Retroviral vectors are widely used tools for gene delivery and gene therapy. They are useful for gene expression studies and genetic manipulation in vitro and in vivo. Many retroviral vectors are derived from the mouse gammaretrovirus, murine leukemia virus (MLV). These vectors have been widely used in gene therapy clinical trials. XMRV, initially found in prostate cancer tissue, was the first human gammaretrovirus described. Findings: We developed a new retroviral vector based on XMRV called pXC. It was developed for gene transfer to human cells and is produced by transient cotransfection of LNCaP cells with pXC and XMRV-packaging plasmids. Conclusions: We demonstrated that pXC mediates expression of inserted transgenes in cell lines. This new vector will be a useful tool for gene transfer in human and non-human cell lines, including gene therapy studies.

Tipo de elemento: Article
Palabras claves no controlados: XMRV; Retroviral vector; Transduction
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Cervantes García, DanielNO ESPECIFICADONO ESPECIFICADO
Rojas Martínez, AugustoNO ESPECIFICADONO ESPECIFICADO
Camerini, DavidNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 06 Mayo 2019 20:39
Última modificación: 06 Mayo 2019 20:39
URI: http://eprints.uanl.mx/id/eprint/15064

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