Mode of antiviral action of silver nanoparticles against HIV-1

Lara, Humberto H y Ayala Nuñez, Nilda V y Ixtepan Turrent, Liliana del Carmen y Rodriguez Padilla, Cristina (2010) Mode of antiviral action of silver nanoparticles against HIV-1. Journal of Nanobiotechnology, 8 (1). p. 1. ISSN 1477-3155

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URL o página oficial: http://doi.org/10.1186/1477-3155-8-1

Resumen

Background: Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays. Results: Our data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cellfree virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle. Conclusions: These properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains.

Tipo de elemento: Article
Divisiones: Ciencias Biológicas
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Lara, Humberto HNO ESPECIFICADONO ESPECIFICADO
Ayala Nuñez, Nilda VNO ESPECIFICADONO ESPECIFICADO
Ixtepan Turrent, Liliana del CarmenNO ESPECIFICADONO ESPECIFICADO
Rodriguez Padilla, CristinaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 29 Abr 2019 18:41
Última modificación: 12 Jun 2019 08:03
URI: http://eprints.uanl.mx/id/eprint/15088

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