Leishmania (L.) mexicana infected bats in Mexico: novel potential reservoirs

Berzunza Cruz, Miriam y Rodríguez Moreno, Ángel y Gutiérrez Granados, Gabriel y González Salazar, Constantino y Stephens, Christopher R. y Hidalgo Mihart, Mircea y Marina Fernández, Carlos F. y Rebollar Téllez, Eduardo Alfonso y Bailón Martínez, Dulce y Balcells, Cristina Domingo y Ibarra Cerdeña, Carlos N. y Sánchez Cordero, Víctor y Becker, Ingeborg (2015) Leishmania (L.) mexicana infected bats in Mexico: novel potential reservoirs. PloS Neglected tropical diseases, 9 (1). e0003438. ISSN 1935-2727

[img]
Vista previa
Texto
222.PDF - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Vista previa

Resumen

Leishmania (Leishmania) mexicana causes cutaneous leishmaniasis, an endemic zoonosis affecting a growing number of patients in the southeastern states of Mexico. Some foci are found in shade-grown cocoa and coffee plantations, or near perennial forests that provide rich breeding grounds for the sand fly vectors, but also harbor a variety of bat species that live off the abundant fruits provided by these shade-giving trees. The close proximity between sand flies and bats makes their interaction feasible, yet bats infected with Leishmania (L.) mexicana have not been reported. Here we analyzed 420 bats from six states of Mexico that had reported patients with leishmaniasis. Tissues of bats, including skin, heart, liver and/or spleen were screened by PCR for Leishmania (L.) mexicana DNA. We found that 41 bats (9.77%), belonging to 13 species, showed positive PCR results in various tissues. The infected tissues showed no evidence of macroscopic lesions. Of the infected bats, 12 species were frugivorous, insectivorous or nectarivorous, and only one species was sanguivorous (Desmodus rotundus), and most of them belonged to the family Phyllostomidae. The eco-region where most of the infected bats were caught is the Gulf Coastal Plain of Chiapas and Tabasco. Through experimental infections of two Tadarida brasiliensis bats in captivity, we show that this species can harbor viable, infective Leishmania (L.) mexicana parasites that are capable of infecting BALB/c mice. We conclude that various species of bats belonging to the family Phyllostomidae are possible reservoir hosts for Leishmania (L.) mexicana, if it can be shown that such bats are infective for the sand fly vector. Further studies are needed to determine how these bats become infected, how long the parasite remains viable inside these potential hosts and whether they are infective to sand flies to fully evaluate their impact on disease epidemiology.

Tipo de elemento: Article
Divisiones: Ciencias Biológicas
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Berzunza Cruz, MiriamNO ESPECIFICADONO ESPECIFICADO
Rodríguez Moreno, ÁngelNO ESPECIFICADONO ESPECIFICADO
Gutiérrez Granados, GabrielNO ESPECIFICADONO ESPECIFICADO
González Salazar, ConstantinoNO ESPECIFICADONO ESPECIFICADO
Stephens, Christopher R.NO ESPECIFICADONO ESPECIFICADO
Hidalgo Mihart, MirceaNO ESPECIFICADONO ESPECIFICADO
Marina Fernández, Carlos F.NO ESPECIFICADONO ESPECIFICADO
Rebollar Téllez, Eduardo AlfonsoNO ESPECIFICADONO ESPECIFICADO
Bailón Martínez, DulceNO ESPECIFICADONO ESPECIFICADO
Balcells, Cristina DomingoNO ESPECIFICADONO ESPECIFICADO
Ibarra Cerdeña, Carlos N.NO ESPECIFICADONO ESPECIFICADO
Sánchez Cordero, VíctorNO ESPECIFICADONO ESPECIFICADO
Becker, IngeborgNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 12 Abr 2019 20:04
Última modificación: 05 Mar 2020 22:53
URI: http://eprints.uanl.mx/id/eprint/15112

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year