Antiprotozoal activity against entamoeba histolytica of plants used in Northeast Mexican traditional medicine. Bioactive compounds from lippia graveolens and ruta chalepensis

Quintanilla Licea, Ramiro y Mata Cárdenas, Benito David y Vargas Villarreal, Javier y Bazaldúa Rodríguez, Aldo Fabio y Kavimngeles Hernández, Isvar y Garza González, Jesús Norberto y Hernández García, Magda Elizabeth (2014) Antiprotozoal activity against entamoeba histolytica of plants used in Northeast Mexican traditional medicine. Bioactive compounds from lippia graveolens and ruta chalepensis. Molecules, 19 (12). pp. 21044-21065. ISSN 1420-3049

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URL o página oficial: http://doi.org/10.3390/molecules191221044

Resumen

Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries. Because of the side-effects and the resistance that pathogenic protozoa build against the standard antiparasitic drugs, e.g., metronidazole, much recent attention has been paid to plants used in traditional medicine around the world in order to find new antiprotozoal agents. We collected 32 plants used in Northeast Mexican traditional medicine and the methanolic extracts of these species were screened for antiprotozoal activity against E. histolytica trophozoites using in vitro tests. Only 18 extracts showed a significant inhibiting activity and among them six plant extracts showed more than 80% growth inhibition against E. histolytica at a concentration of 150 µg/mL and the IC50 values of these extracts were determined. Lippia graveolens Kunth and Ruta chalepensis Pers. showed the more significant antiprotozoal activity (91.54% and 90.50% growth inhibition at a concentration of 150 µg/mL with IC50 values of 59.14 and 60.07 µg/mL, respectively). Bioassay-guided fractionation of the methanolic extracts from these two plants afforded carvacrol (1) and chalepensin (2), respectively, as bioactive compounds with antiprotozoal activity.

Tipo de elemento:

Article

Palabras claves no controlados:

Neglected diseases, Amoebiasis, Mexican medicinal plants, Bioguided isolation, Carvacrol, Chalepensin, Antiprotozoal agents, 1D- and 2D-NMR data

Materias:

Q Ciencia > QK Botánica

Divisiones:

Ciencias Biológicas

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Quintanilla Licea, Ramiro	ramiro.quintanillalc@uanl.edu.mx	orcid.org/0000-0002-4379-6913
Mata Cárdenas, Benito David	NO ESPECIFICADO	NO ESPECIFICADO
Vargas Villarreal, Javier	NO ESPECIFICADO	NO ESPECIFICADO
Bazaldúa Rodríguez, Aldo Fabio	NO ESPECIFICADO	NO ESPECIFICADO
Kavimngeles Hernández, Isvar	NO ESPECIFICADO	NO ESPECIFICADO
Garza González, Jesús Norberto	NO ESPECIFICADO	NO ESPECIFICADO
Hernández García, Magda Elizabeth	NO ESPECIFICADO	NO ESPECIFICADO