Antiprotozoal activity against entamoeba histolytica of plants used in Northeast Mexican traditional medicine. Bioactive compounds from lippia graveolens and ruta chalepensis

Quintanilla Licea, Ramiro y Mata Cárdenas, Benito David y Vargas Villarreal, Javier y Bazaldúa Rodríguez, Aldo Fabio y Kavimngeles Hernández, Isvar y Garza González, Jesús Norberto y Hernández García, Magda Elizabeth (2014) Antiprotozoal activity against entamoeba histolytica of plants used in Northeast Mexican traditional medicine. Bioactive compounds from lippia graveolens and ruta chalepensis. Molecules, 19 (12). pp. 21044-21065. ISSN 1420-3049

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Resumen

Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries. Because of the side-effects and the resistance that pathogenic protozoa build against the standard antiparasitic drugs, e.g., metronidazole, much recent attention has been paid to plants used in traditional medicine around the world in order to find new antiprotozoal agents. We collected 32 plants used in Northeast Mexican traditional medicine and the methanolic extracts of these species were screened for antiprotozoal activity against E. histolytica trophozoites using in vitro tests. Only 18 extracts showed a significant inhibiting activity and among them six plant extracts showed more than 80% growth inhibition against E. histolytica at a concentration of 150 µg/mL and the IC50 values of these extracts were determined. Lippia graveolens Kunth and Ruta chalepensis Pers. showed the more significant antiprotozoal activity (91.54% and 90.50% growth inhibition at a concentration of 150 µg/mL with IC50 values of 59.14 and 60.07 µg/mL, respectively). Bioassay-guided fractionation of the methanolic extracts from these two plants afforded carvacrol (1) and chalepensin (2), respectively, as bioactive compounds with antiprotozoal activity.

Tipo de elemento: Article
Palabras claves no controlados: Neglected diseases, Amoebiasis, Mexican medicinal plants, Bioguided isolation, Carvacrol, Chalepensin, Antiprotozoal agents, 1D- and 2D-NMR data
Materias: Q Ciencia > QK Botánica
Divisiones: Ciencias Biológicas
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Quintanilla Licea, Ramiroramiro.quintanillalc@uanl.edu.mxorcid.org/0000-0002-4379-6913
Mata Cárdenas, Benito DavidNO ESPECIFICADONO ESPECIFICADO
Vargas Villarreal, JavierNO ESPECIFICADONO ESPECIFICADO
Bazaldúa Rodríguez, Aldo FabioNO ESPECIFICADONO ESPECIFICADO
Kavimngeles Hernández, IsvarNO ESPECIFICADONO ESPECIFICADO
Garza González, Jesús NorbertoNO ESPECIFICADONO ESPECIFICADO
Hernández García, Magda ElizabethNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 09 Abr 2019 22:07
Última modificación: 09 Abr 2019 22:07
URI: http://eprints.uanl.mx/id/eprint/15121

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