CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

García Labastida, Laura y Garza Guajardo, Raquel y Barboza Quintana, Oralia y Rodríguez Sánchez, Iram Pablo y Ancer Rodríguez, Jesús y Flores Gutiérrez, Juan Pablo y Gómez Macías, Gabriela Sofía (2014) CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast. Biological Research, 47 (1). pp. 43-47. ISSN 0717-6287

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Resumen

Background: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. Results: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. Conclusions: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.

Tipo de elemento: Article
Palabras claves no controlados: Breast mucinous carcinoma; Inmunohistochemical; Intestinal differentiation
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
García Labastida, LauraNO ESPECIFICADONO ESPECIFICADO
Garza Guajardo, RaquelNO ESPECIFICADONO ESPECIFICADO
Barboza Quintana, OraliaNO ESPECIFICADONO ESPECIFICADO
Rodríguez Sánchez, Iram PabloNO ESPECIFICADONO ESPECIFICADO
Ancer Rodríguez, JesúsNO ESPECIFICADONO ESPECIFICADO
Flores Gutiérrez, Juan PabloNO ESPECIFICADONO ESPECIFICADO
Gómez Macías, Gabriela SofíaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 19 Mar 2019 22:37
Última modificación: 04 Feb 2020 21:10
URI: http://eprints.uanl.mx/id/eprint/15220

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