Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by nocardia brasiliensis

Espinoza González, Nelly Alejandra y Welsh Lozano, Oliverio y De Torres, Noemi Waksman y Cavazos Rocha, Norma Cecilia y Ocampo Candiani, Jorge y Said Fernández, Salvador y Lozano Garza, Gerardo y Choi, Sung Hak y Vera Cabrera, Lucio (2008) Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by nocardia brasiliensis. Molecules, 13 (1). pp. 31-40. ISSN 1420-3049

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Resumen

Two recently synthesized oxazolidinones: (R)-3-(4-(2-(2-methyltetrazol-5-yl)- pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (DA-7157) and its corresponding pro-drug (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)- 2-oxo-5-oxazolidinyl) methyl disodium phosphate (DA-7218), have shown very good activity against several Gram positive bacteria, including Nocardia and Mycobacterium. In the present work we evaluated the therapeutic in vivo effects of DA-7218 on Nocardia brasiliensis. We first determined the plasma concentration of the prodrug in BALB/c mice using several doses and then tested its activity in an in vivo experimental actinomycetoma murine model. At the end of treatment, there was a statistically significant difference between the three drug receiving groups (25, 12.5 and 5 mg/kg) and the control group (saline solution) (p=0.001), proving that DA-7218 is effective for the treatment of experimental murine actinomycetoma. This compound could be a potential option for patients affected with mycetoma by Nocardia brasiliensis.

Tipo de elemento: Article
Palabras claves no controlados: Actinomycetoma, Oxazolidinones, Prodrug, Nocardia brasiliensis
Materias: Q Ciencia > QR Microbiología
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Espinoza González, Nelly AlejandraNO ESPECIFICADONO ESPECIFICADO
Welsh Lozano, OliverioNO ESPECIFICADONO ESPECIFICADO
De Torres, Noemi WaksmanNO ESPECIFICADONO ESPECIFICADO
Cavazos Rocha, Norma CeciliaNO ESPECIFICADONO ESPECIFICADO
Ocampo Candiani, JorgeNO ESPECIFICADONO ESPECIFICADO
Said Fernández, SalvadorNO ESPECIFICADONO ESPECIFICADO
Lozano Garza, GerardoNO ESPECIFICADONO ESPECIFICADO
Choi, Sung HakNO ESPECIFICADONO ESPECIFICADO
Vera Cabrera, LucioNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 11 Ene 2019 23:10
Última modificación: 09 Dic 2024 17:31
URI: http://eprints.uanl.mx/id/eprint/15281

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