Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico

Saavedra Rodriguez, Karla y Maloof, Farah Vera y Campbell, Corey L. y Garcia Rejon, Julian y Lenhart, Audrey y Penilla, Patricia y Rodriguez, Americo y Sandoval, Arturo Acero y Flores, Adriana E. y Ponce, Gustavo y Lozano, Saul y Black, William C. (2018) Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico. Scientific Reports, 8 (1). pp. 1-9. ISSN 2045-2322

[img]
Vista previa
Texto
39.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Vista previa

Resumen

Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and efective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid spacesprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identifed in Brazil and its efect on vgsc was confrmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the frst heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specifc vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management.

Tipo de elemento: Article
Materias: Q Ciencia > QR Microbiología
Divisiones: Ciencias Biológicas
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Saavedra Rodriguez, KarlaNO ESPECIFICADONO ESPECIFICADO
Maloof, Farah VeraNO ESPECIFICADONO ESPECIFICADO
Campbell, Corey L.NO ESPECIFICADONO ESPECIFICADO
Garcia Rejon, JulianNO ESPECIFICADONO ESPECIFICADO
Lenhart, AudreyNO ESPECIFICADONO ESPECIFICADO
Penilla, PatriciaNO ESPECIFICADONO ESPECIFICADO
Rodriguez, AmericoNO ESPECIFICADONO ESPECIFICADO
Sandoval, Arturo AceroNO ESPECIFICADONO ESPECIFICADO
Flores, Adriana E.NO ESPECIFICADONO ESPECIFICADO
Ponce, GustavoNO ESPECIFICADONO ESPECIFICADO
Lozano, SaulNO ESPECIFICADONO ESPECIFICADO
Black, William C.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 18 Jun 2020 15:53
Última modificación: 18 Jun 2020 15:53
URI: http://eprints.uanl.mx/id/eprint/15966

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year