Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii
García Davis, Sara y Sifaoui, Ines y Reyes Batlle, María y Viveros Valdez, José Ezequiel y Piñero, José y Lorenzo Morales, Jacob y Fernández, José J. y Díaz Marrero, Ana (2018) Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii. Marine drugs, 16 (11). pp. 1-12. ISSN 1660-3397
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Texto
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Resumen
Focusedonourinteresttodevelopnovelantiparasisticagents,thepresentstudywasaimed to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja California Sur, Mexico, against an Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us to identify the amoebicidal diastereoisomers α-bromocuparane (4) and α-isobromocuparane (5). Furthermore, bromination of the inactive laurinterol (1) and isolaurinterol (2) yielded four halogenated derivatives, (6)–(9), which improved the activity of the natural sesquiterpenes. Among them, the most active compound was 3α-bromojohnstane (7), a sesquiterpene derivative which possesses a novel carbon skeleton johnstane.
Tipo de elemento: | Article | |||||||||||||||||||||||||||
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Materias: | R Medicina > RS Farmacia y Materia Médica | |||||||||||||||||||||||||||
Divisiones: | Ciencias Biológicas | |||||||||||||||||||||||||||
Usuario depositante: | Lic. Josimar Pulido | |||||||||||||||||||||||||||
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Fecha del depósito: | 02 Jul 2020 11:26 | |||||||||||||||||||||||||||
Última modificación: | 04 Mar 2024 16:48 | |||||||||||||||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/15976 |
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