Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico

Galán Huerta, Kame y Martínez Landeros, Erik y Delgado Gallegos, Juan y Caballero Sosa, Sandra y Malo García, Iliana y Fernández Salas, Ildefonso y Ramos Jiménez, Javier y Rivas Estilla, Ana (2018) Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico. Viruses, 10 (5). pp. 1-18. ISSN 1999-4915

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URL o página oficial: http://doi.org/10.3390/v10050248

Resumen

Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information. The aim of this study was to perform a full description of the clinical features in confirmed Chikungunya-infected patients and describe the molecular epidemiology of CHIKV. We evaluated febrile patients who sought medical assistance in Tapachula, Chiapas, Mexico, from June through July 2015. Infection was confirmed with molecular and serological methods. Viruses were isolated and the E1 gene was sequenced. Phylogeny reconstruction was inferred using maximum-likelihood and maximum clade credibility approaches. We studied 52 patients with confirmed CHIKV infection. They were more likely to have wrist, metacarpophalangeal, and knee arthralgia. Two combinations of clinical features were obtained to differentiate between Chikungunya fever and acute undifferentiated febrile illness. We obtained 10 CHIKV E1 sequences that grouped with the Asian lineage. Seven strains diverged from the formerly reported. Patients infected with the divergent CHIKV strains showed a broader spectrum of clinical manifestations. We defined the complete clinical features of Chikungunya fever in patients from Southeastern Mexico. Our results demonstrate co-circulation of different CHIKV strains in the state of Chiapas.

Tipo de elemento: Article
Materias: Q Ciencia > QR Microbiología
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Galán Huerta, KameNO ESPECIFICADONO ESPECIFICADO
Martínez Landeros, ErikNO ESPECIFICADONO ESPECIFICADO
Delgado Gallegos, JuanNO ESPECIFICADONO ESPECIFICADO
Caballero Sosa, SandraNO ESPECIFICADONO ESPECIFICADO
Malo García, IlianaNO ESPECIFICADONO ESPECIFICADO
Fernández Salas, IldefonsoNO ESPECIFICADONO ESPECIFICADO
Ramos Jiménez, JavierNO ESPECIFICADONO ESPECIFICADO
Rivas Estilla, AnaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 18 Jun 2020 20:01
Última modificación: 18 Jun 2020 20:01
URI: http://eprints.uanl.mx/id/eprint/16232

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