Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo León State, México

Reyna Martinez, Raul y Gómez Flores, Ricardo Alberto y Lopez Chuken, Ulrico Javier y Quintanilla Licea, Ramiro y Caballero Hernández, Diana Elia y Rodríguez Padilla, Cristina y Beltrán Rocha, Julio César y Tamez Guerra, Patricia (2018) Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo León State, México. PeerJ, 6. pp. 1-15. ISSN 2167-8359

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URL o página oficial: http://doi.org/10.7717/peerj.4358

Resumen

ABSTRACT Cancer cases result in 13% of all deaths worldwide. Unwanted side effects in patients underconventionaltreatmentshaveledtothesearchforbeneficialalternativetherapies. Microalgae synthesize compounds with known invitro and invivo biological activity againstdifferenttumorcelllines.Therefore,nativemicroalgaefromtheStateofNuevo Leon, Mexico may become a potential source of antitumor agents. The aim of the present study was to evaluate the invitro cytotoxic effect of Nuevo Leon regional Chlorella sorokiniana (Chlorellales: Chlorellaceae) and Scenedesmus sp. (Chlorococcales: Scenedesmaceae). Native microalgae crude organic extracts cytotoxicity against murine L5178Y-R lymphoma cell line and normal lymphocyte proliferation were evaluatedusingtheMTTreductioncolorimetricassay.Celldeathpathwaywasanalyzed byacridineorangeandethidiumbromidestaining,DNAdegradationin2%agarosegel electrophoresis and caspases activity. Results indicated significant (p<0.05) 61.89% ±3.26% and 74.77%±1.84% tumor cytotoxicity by C.sorokiniana and Scenedesmus sp.methanolextracts,respectively,at500 µg/mL,bythemechanismofapoptosis.This studycontributestoMexicanmicroalgaebiodiversityknowledgeandtheirpotentialas antitumor agent sources.

Tipo de elemento: Article
Divisiones: Ciencias Químicas
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Reyna Martinez, RaulNO ESPECIFICADONO ESPECIFICADO
Gómez Flores, Ricardo Albertoricardo.gomezfl@uanl.edu.mxNO ESPECIFICADO
Lopez Chuken, Ulrico JavierNO ESPECIFICADONO ESPECIFICADO
Quintanilla Licea, RamiroNO ESPECIFICADONO ESPECIFICADO
Caballero Hernández, Diana EliaNO ESPECIFICADONO ESPECIFICADO
Rodríguez Padilla, CristinaNO ESPECIFICADONO ESPECIFICADO
Beltrán Rocha, Julio CésarNO ESPECIFICADONO ESPECIFICADO
Tamez Guerra, PatriciaNO ESPECIFICADOorcid.org/0000-0002-4831-2340
Fecha del depósito: 31 Jul 2019 21:02
Última modificación: 05 Mar 2024 16:05
URI: http://eprints.uanl.mx/id/eprint/16340

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