Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo León State, México
Reyna Martinez, Raul y Gómez Flores, Ricardo Alberto y Lopez Chuken, Ulrico Javier y Quintanilla Licea, Ramiro y Caballero Hernández, Diana Elia y Rodríguez Padilla, Cristina y Beltrán Rocha, Julio César y Tamez Guerra, Patricia (2018) Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo León State, México. PeerJ, 6. pp. 1-15. ISSN 2167-8359
|
Texto
188.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (4MB) | Vista previa |
Resumen
ABSTRACT Cancer cases result in 13% of all deaths worldwide. Unwanted side effects in patients underconventionaltreatmentshaveledtothesearchforbeneficialalternativetherapies. Microalgae synthesize compounds with known invitro and invivo biological activity againstdifferenttumorcelllines.Therefore,nativemicroalgaefromtheStateofNuevo Leon, Mexico may become a potential source of antitumor agents. The aim of the present study was to evaluate the invitro cytotoxic effect of Nuevo Leon regional Chlorella sorokiniana (Chlorellales: Chlorellaceae) and Scenedesmus sp. (Chlorococcales: Scenedesmaceae). Native microalgae crude organic extracts cytotoxicity against murine L5178Y-R lymphoma cell line and normal lymphocyte proliferation were evaluatedusingtheMTTreductioncolorimetricassay.Celldeathpathwaywasanalyzed byacridineorangeandethidiumbromidestaining,DNAdegradationin2%agarosegel electrophoresis and caspases activity. Results indicated significant (p<0.05) 61.89% ±3.26% and 74.77%±1.84% tumor cytotoxicity by C.sorokiniana and Scenedesmus sp.methanolextracts,respectively,at500 µg/mL,bythemechanismofapoptosis.This studycontributestoMexicanmicroalgaebiodiversityknowledgeandtheirpotentialas antitumor agent sources.
Tipo de elemento: | Article | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Divisiones: | Ciencias Químicas | |||||||||||||||||||||||||||
Usuario depositante: | Lic. Josimar Pulido | |||||||||||||||||||||||||||
Creadores: |
|
|||||||||||||||||||||||||||
Fecha del depósito: | 31 Jul 2019 21:02 | |||||||||||||||||||||||||||
Última modificación: | 05 Mar 2024 16:05 | |||||||||||||||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/16340 |
Actions (login required)
Ver elemento |