Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo León State, México

Reyna Martinez, Raul y Gómez Flores, Ricardo Alberto y Lopez Chuken, Ulrico Javier y Quintanilla Licea, Ramiro y Caballero Hernández, Diana Elia y Rodríguez Padilla, Cristina y Beltrán Rocha, Julio César y Tamez Guerra, Patricia (2018) Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo León State, México. PeerJ, 6. pp. 1-15. ISSN 2167-8359

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Resumen

ABSTRACT Cancer cases result in 13% of all deaths worldwide. Unwanted side effects in patients underconventionaltreatmentshaveledtothesearchforbeneficialalternativetherapies. Microalgae synthesize compounds with known invitro and invivo biological activity againstdifferenttumorcelllines.Therefore,nativemicroalgaefromtheStateofNuevo Leon, Mexico may become a potential source of antitumor agents. The aim of the present study was to evaluate the invitro cytotoxic effect of Nuevo Leon regional Chlorella sorokiniana (Chlorellales: Chlorellaceae) and Scenedesmus sp. (Chlorococcales: Scenedesmaceae). Native microalgae crude organic extracts cytotoxicity against murine L5178Y-R lymphoma cell line and normal lymphocyte proliferation were evaluatedusingtheMTTreductioncolorimetricassay.Celldeathpathwaywasanalyzed byacridineorangeandethidiumbromidestaining,DNAdegradationin2%agarosegel electrophoresis and caspases activity. Results indicated significant (p<0.05) 61.89% ±3.26% and 74.77%±1.84% tumor cytotoxicity by C.sorokiniana and Scenedesmus sp.methanolextracts,respectively,at500 µg/mL,bythemechanismofapoptosis.This studycontributestoMexicanmicroalgaebiodiversityknowledgeandtheirpotentialas antitumor agent sources.

Tipo de elemento:	Article
Divisiones:	Ciencias Químicas
Usuario depositante:	Lic. Josimar Pulido
Creadores:	Creador Email ORCID Reyna Martinez, Raul NO ESPECIFICADO NO ESPECIFICADO Gómez Flores, Ricardo Alberto ricardo.gomezfl@uanl.edu.mx NO ESPECIFICADO Lopez Chuken, Ulrico Javier NO ESPECIFICADO NO ESPECIFICADO Quintanilla Licea, Ramiro NO ESPECIFICADO NO ESPECIFICADO Caballero Hernández, Diana Elia NO ESPECIFICADO NO ESPECIFICADO Rodríguez Padilla, Cristina NO ESPECIFICADO NO ESPECIFICADO Beltrán Rocha, Julio César NO ESPECIFICADO NO ESPECIFICADO Tamez Guerra, Patricia NO ESPECIFICADO orcid.org/0000-0002-4831-2340
Fecha del depósito:	31 Jul 2019 21:02
Última modificación:	05 Mar 2024 16:05
URI:	http://eprints.uanl.mx/id/eprint/16340

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