Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease

Góngora Rivera, Fernando y Cordero Pérez, Adolfo y González Aquines, Alejandro y Anaya Escamilla, Antonio y Villarreal Garza, Eduardo y Espinosa Ortega, Meztli y Salinas Carmona, Mario César y Ortiz Jiménez, Xóchitl A. (2018) Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease. International Journal of Alzheimer's Disease, 2018. pp. 1-5. ISSN 2090-8024

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URL o página oficial: http://doi.org/10.1155/2018/9328293

Resumen

Background. Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease. Cerebral vasomotor reactivity could be an important biomarker for this pathology. Aims. The aim of this study was to investigate the alterations in cerebralvascularmotorreactivityinAlzheimer’sdiseasesubjectsandtoassociatethesechangeswiththeircognitivescores.Methods. WerecruitedsubjectswithadiagnosisofAlzheimer’sdiseaseandhealthycontrols.Demographic,clinical,imaging,andcognitive testwereobtained.Thenallparticipantsperformedacerebralvascularmotorreactivitytestwith7%CO2andcerebralbloodflow velocities(CBFV)wererecordedwithtranscranialdopplerultrasoundbeforeandafterthetest.Results.Werecruited45subjects, 26(21female)Alzheimer’sdiseaseparticipantsand19(15female)healthycontrols.Therewerenodifferencesinbaselinecerebral blood flow velocities between the groups. After the cerebral vasomotor reactivity test, absolute mean difference in mean CBFV (ΔCBFV-m)was 8.70±4.14 versus4.81±6.96 (p<0.01), respectively.Calculatedpercentage of change (%CVMR) was lower in the ADgroup7.45±18.25versus23.29±17.48,andtherewasapositivebutweakcorrelationwithmini-mentalscores(

Tipo de elemento: Article
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Góngora Rivera, Fernandofernando.gongora@hotmail.comNO ESPECIFICADO
Cordero Pérez, AdolfoNO ESPECIFICADONO ESPECIFICADO
González Aquines, AlejandroNO ESPECIFICADONO ESPECIFICADO
Anaya Escamilla, AntonioNO ESPECIFICADONO ESPECIFICADO
Villarreal Garza, EduardoNO ESPECIFICADONO ESPECIFICADO
Espinosa Ortega, MeztliNO ESPECIFICADONO ESPECIFICADO
Salinas Carmona, Mario CésarNO ESPECIFICADONO ESPECIFICADO
Ortiz Jiménez, Xóchitl A.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 23 Ago 2019 21:02
Última modificación: 20 Abr 2021 15:57
URI: http://eprints.uanl.mx/id/eprint/16623

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