The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

Garay Mendoza, Domingo y Villarreal Martínez, Laura y Garza Bedolla, Alejandra y Pérez Garza, Daniela M. y Acosta Olivo, Carlos Alberto y Vílchez Cavazos, Félix y Diaz Hutchinson, Cesar y Gómez Almaguer, David y Jaime Pérez, José Carlos y Mancías Guerra, Consuelo (2017) The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis. International Journal of Rheumatic Diseases, 21 (1). pp. 140-147. ISSN 17561841

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Abstract Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA. Method: This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G-CSF). SC were obtained by BM aspiration and administered in a single intra-articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT01485198. Results: A total of 61 patients were included. Socio-demographic characteristics, OA grades and initial scores were similar in both groups. The BM-SC group showed significant improvement in knee pain and quality of life during the 6-month follow-up. Conclusion: The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA. Key words: bone marrow, knee osteoarthritis, stem cells.

Tipo de elemento: Article
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Garay Mendoza, DomingoNO ESPECIFICADONO ESPECIFICADO
Villarreal Martínez, LauraNO ESPECIFICADONO ESPECIFICADO
Garza Bedolla, AlejandraNO ESPECIFICADONO ESPECIFICADO
Pérez Garza, Daniela M.NO ESPECIFICADONO ESPECIFICADO
Acosta Olivo, Carlos AlbertoNO ESPECIFICADONO ESPECIFICADO
Vílchez Cavazos, FélixNO ESPECIFICADONO ESPECIFICADO
Diaz Hutchinson, CesarNO ESPECIFICADONO ESPECIFICADO
Gómez Almaguer, DavidNO ESPECIFICADONO ESPECIFICADO
Jaime Pérez, José CarlosNO ESPECIFICADONO ESPECIFICADO
Mancías Guerra, ConsueloNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 06 Mayo 2020 17:06
Última modificación: 28 Oct 2020 15:28
URI: http://eprints.uanl.mx/id/eprint/17145

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