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The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis
Garay Mendoza, Domingo y Villarreal Martínez, Laura y Garza Bedolla, Alejandra y Pérez Garza, Daniela Michelle y Acosta Olivo, Carlos Alberto y Vílchez Cavazos, José Félix y Diaz Hutchinson, Cesar y Gómez Almaguer, David y Jaime Pérez, José Carlos y Mancías Guerra, Consuelo (2017) The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis. International Journal of Rheumatic Diseases, 21 (1). pp. 140-147. ISSN 17561841
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Resumen
Abstract Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA. Method: This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G-CSF). SC were obtained by BM aspiration and administered in a single intra-articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT01485198. Results: A total of 61 patients were included. Socio-demographic characteristics, OA grades and initial scores were similar in both groups. The BM-SC group showed significant improvement in knee pain and quality of life during the 6-month follow-up. Conclusion: The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA. Key words: bone marrow, knee osteoarthritis, stem cells.
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| Divisiones: | Medicina | |||||||||||||||||||||||||||||||||
| Usuario depositante: | Lic. Josimar Pulido | |||||||||||||||||||||||||||||||||
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| Fecha del depósito: | 06 Mayo 2020 17:06 | |||||||||||||||||||||||||||||||||
| Última modificación: | 25 Mayo 2023 18:58 | |||||||||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/17145 |
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