In Vitro Study of Antiamoebic Activity of Methanol Extracts of Argemone mexicana on Trophozoites of Entamoeba histolytica HM1-IMSS

Elizondo Luévano, Joel Horacio y Castro Ríos, Rocío y Sánchez García, Eduardo y Hernández García, Magda Elizabeth y Vargas Villarreal, Javier y Rodríguez Luis, Osvelia Esmeralda y Chávez Montes, Abelardo (2018) In Vitro Study of Antiamoebic Activity of Methanol Extracts of Argemone mexicana on Trophozoites of Entamoeba histolytica HM1-IMSS. Canadian Journal of Infectious Diseases and Medical Microbiology, 2018. pp. 1-8. ISSN 1712-9532

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URL o página oficial: http://doi.org/10.1155/2018/7453787

Resumen

Infections caused by parasites in humans represent one of the main public health concerns. Amoebiasis, a parasitic infection caused by Entamoeba histolytica (E. histolytica), is considered endemic in Mexico, where Argemone mexicana (A. mexicana) has been used in traditional medicine to treat intestinal parasitic diseases. ,e objective of this work was to evaluate the potential biological activity of A. mexicana on E. histolytica. For this purpose, a methanolic extract was prepared from A. mexicana leaves, and a differential fractionation was carried out with solvents of different polarities. The inhibitory capacities of the extract and its fractions were evaluated in vitro using HM1-IMSS, a strain of Entamoeba histolytica. A. mexicana extract was found to have a growth-inhibiting activity for E. histolytica, showing IC50 = 78.39 μg/mL. The extract was characterized phytochemically, and the methanolic extract fractions were analyzed by liquid chromatography (HPLC) and mass spectrometry (MS). Berberine and jatrorrhizine were present in the active fractions, and these compounds may be responsible for the antiparasitic activity. The identification of amoebicidal activity of A. mexicana on E. histolytica gives su pport to the traditional use. Further studies withberberine and jatrorrhizine will be carried out to understand the mechanism involved.

Tipo de elemento: Article
Materias: Q Ciencia > QR Microbiología
R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Ciencias Biológicas
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Elizondo Luévano, Joel HoracioNO ESPECIFICADONO ESPECIFICADO
Castro Ríos, RocíoNO ESPECIFICADONO ESPECIFICADO
Sánchez García, EduardoNO ESPECIFICADONO ESPECIFICADO
Hernández García, Magda ElizabethNO ESPECIFICADONO ESPECIFICADO
Vargas Villarreal, JavierNO ESPECIFICADONO ESPECIFICADO
Rodríguez Luis, Osvelia EsmeraldaNO ESPECIFICADONO ESPECIFICADO
Chávez Montes, AbelardoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 20 Mayo 2020 13:47
Última modificación: 08 Jun 2020 19:12
URI: http://eprints.uanl.mx/id/eprint/17152

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