Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring

Montalvo Martínez, Larisa Jajaira y Maldonado Ruiz, Roger Alexis y Cárdenas Tueme, Marcela y Reséndez Pérez, Diana y Camacho, Alberto (2018) Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring. BioMed Research International, 2018. pp. 1-11. ISSN 2314-6133

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Resumen

Obesityormaternalovernutritionduringpregnancyandlactationmighthavelong-termconsequencesinoffspringhealth.Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages. Programming alters gene expression through epigenetic modifications leading to a transgenerational effect of behavioral phenotypes in the offspring. Maternal intake of hypercaloric diets during fetal development programs aberrant behaviors resembling addiction in offspring.Programmingbyhypercaloricsurplussetsageneexpressionpatternmodulatingaxonalpruning,synapticsignaling,and synapticplasticityinselectiveregionsoftherewardsystem.Likewise,fetalprogrammingcanpromoteaninflammatoryphenotype inperipheralandcentralsitesthroughdifferentcelltypessuchasmicrogliaandTandBcells,whichcontributetodisruptedenergy sensing and behavioral pathways. The molecular mechanism that regulates the central and peripheral immune cross-talk during fetalprogramminganditsrelevanceonoffspring’saddictivebehaviorsusceptibilityisstillunclear.Here,wereviewthemostrelevant scientificreportsabouttheimpactofhypercaloricnutritionalfetalprogrammingoncentralandperipheralinflammationandits effectsonaddictivebehavioroftheoffspring.

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