Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis

Camara Lemarroy, Carlos Rodrigo y Delgado García, Guillermo Rubén y De la Cruz González, Juan Gilberto y Villareal Velázquez, Héctor Jorge y Gongora Rivera, Fernando (2016) Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis. The Journal of Infection in Developing Countries, 11 (02). pp. 166-172. ISSN 1972-2680

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URL o página oficial: http://doi.org/10.3855/jidc.7478

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Abstract Introduction: Mean platelet volume (MPV) has been shown to reflect the inflammatory burden in different inflammatory and autoimmune diseases. Our objective was to analyze the MPV in patients with tuberculous (TBM) and bacterial meningitis (BM). Methodology: The demographic and clinical data of 73 consecutive patients that presented with either BM (n = 35) or TBM (n = 38) were retrospectively analyzed, as well as that of 28 age- and sex-matched controls. Results: MPV was 8.78 ± 1.58 fL in patients with BM and 6.42 ± 1.39 fL in the TBM group (p < 0.05). In the control group, MPV was 7.4 ± 0.66 fL, significantly higher and lower when compared with TBM and BM, respectively. MPV was significantly associated with diagnosis (adjusted OR: 5.15, 95% CI: 1.090–23.7; p = 0.03). With the optimal cut-off value of 7.62 fL, MPV had 82% sensibility and 78% specificity for the differential diagnosis of TBM versus BM. Lower platelet counts, higher serum creatinine, higher white blood cell counts, and higher blood-cerebrospinal fluid glucose ratio were also predictive of BM. Conclusions: Platelet counts were lower and MPV was higher in patients with BM compared to patients with TBM. Platelet indices, available in routine bloodwork, could be useful in the early differential diagnosis of these entities. Key words: meningitis; mean platelet volume; inflammation; platelets; thrombocytopenia.

Tipo de elemento: Article
Palabras claves no controlados: Meningitis, Mean platelet volume, Inflammation, Platelets, Thrombocytopenia.
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Lic. Jesús E. Alvarado
Creadores:
CreadorEmailORCID
Camara Lemarroy, Carlos RodrigoNO ESPECIFICADONO ESPECIFICADO
Delgado García, Guillermo RubénNO ESPECIFICADONO ESPECIFICADO
De la Cruz González, Juan GilbertoNO ESPECIFICADONO ESPECIFICADO
Villareal Velázquez, Héctor JorgeNO ESPECIFICADONO ESPECIFICADO
Gongora Rivera, FernandoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 18 Mar 2020 18:25
Última modificación: 08 Mayo 2020 17:04
URI: http://eprints.uanl.mx/id/eprint/18142

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