Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study

Gallardo Blanco, Hugo Leonid y Villarreal Pérez, Jesús Zacarías y Cerda Flores, Ricardo Martín y Figueroa, Andres y Sánchez Domínguez, Celia Nohemí y Gutiérrez Valverde, Juana Mercedes y Torres Muñoz, Iris Carmen y Lavalle González, Fernando Javier y Gallegos Cabriales, Esther Carlota y Martínez Garza, Laura Elia (2016) Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13 (2). pp. 523-529. ISSN 1792-0981

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URL o página oficial: http://doi.org/10.3892/etm.2016.3990

Resumen

Abstract. The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 SNP rs5210 was associated with T2DM, the TCF7L2 SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the TCF7L2 SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the HNF4A SNP rs1885088 was associated with LDL levels (P<0.05).

Tipo de elemento:

Article

Palabras claves no controlados:

Type 2 diabetes, Association, High-density lipoprotein, Low-density lipoprotein, Cholesterol, Body mass index, Linkage disequilibrium, KCNJ11, TCF7L2, HNF4A

Materias:

R Medicina > R Medicina en General

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Gallardo Blanco, Hugo Leonid	NO ESPECIFICADO	NO ESPECIFICADO
Villarreal Pérez, Jesús Zacarías	NO ESPECIFICADO	NO ESPECIFICADO
Cerda Flores, Ricardo Martín	NO ESPECIFICADO	NO ESPECIFICADO
Figueroa, Andres	NO ESPECIFICADO	NO ESPECIFICADO
Sánchez Domínguez, Celia Nohemí	NO ESPECIFICADO	NO ESPECIFICADO
Gutiérrez Valverde, Juana Mercedes	NO ESPECIFICADO	NO ESPECIFICADO
Torres Muñoz, Iris Carmen	NO ESPECIFICADO	NO ESPECIFICADO
Lavalle González, Fernando Javier	drfernandolavalle@hotmail.com	NO ESPECIFICADO
Gallegos Cabriales, Esther Carlota	esther.gallegoscb@uanl.edu.mx	orcid.org/0000-0003-3619-2596
Martínez Garza, Laura Elia	NO ESPECIFICADO	NO ESPECIFICADO